在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1 (Camk1)

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1 (Camk1)

  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1(Camk1)
  • 貨號：
    CSB-YP852809MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1(Camk1)
  • 貨號：
    CSB-EP852809MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1(Camk1)
  • 貨號：
    CSB-EP852809MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1(Camk1)
  • 貨號：
    CSB-BP852809MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1(Camk1)
  • 貨號：
    CSB-MP852809MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Camk1
  • Uniprot No.：
  • 別名：
    Camk1; Calcium/calmodulin-dependent protein kinase type 1; EC 2.7.11.17; CaM kinase I; CaM-KI; CaM kinase I alpha; CaMKI-alpha
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-374
  • 氨基酸序列
    MPGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKKALEGKE GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TGSHGELLTP TAGGPAAGCC CRDCCVEPGS ELPPAPPPSS RAMD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-673', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
  • 基因功能參考文獻：
    1. report that Parvalbumin positive interneurons employ a novel CaMK-dependent pathway to trigger CREB phosphorylation and gene expression. PMID: 27041500
    2. CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. PMID: 23447692
    3. CaMKI vies with CRM1/exportin 1 for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta-CCTalpha complex is a key effector mechanism that drives nuclear CCTalpha translocation. PMID: 22621903
    4. CaMKIalpha signaling is integral to the Mvarphi responding to LPS and may also be operant in vivo in regulating the inflammation and organ dysfunction consequent to sepsis. PMID: 21372190
    5. Inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain. PMID: 20534813
    6. calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences PMID: 12538590
    7. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI PMID: 15150258
    8. Full-length cDNA encoded am amino acid sequence similar to that of calmodulin kinase I. PMID: 16684769
    9. Interaction of MARK2 with CaMKI results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation. PMID: 17442826
    10. Data identify CaMK1beta as a novel regulator of osteoblast proliferation, via mechanisms that may at least in part involve c-Fos, thus implicating CaMK1beta in the regulation of bone and cartilage development. PMID: 18620088
    11. Our results reveal a previously unrecognized CaM-signaling pathway that endows the VSNs with a mechanism for adjusting gain and sensitivity of chemosensory signaling in the VNO. PMID: 19228965

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：


主站蜘蛛池模板： 精品无码一区二区三区在线| 色窝窝免费播放视频在线| 尤物精品国产第一福利网站| 东京热人妻中文无码av| 日韩人妻无码一区二区三区99| 高清性欧美暴力猛交| 老男人久久青草av高清| 亚洲精品国产成人| 久久久久女教师免费一区| 国产精品成人免费999| 国产成人a∨麻豆精品| 奶头好大狂揉60分钟视频| 日日躁夜夜躁狠狠躁超碰97| 香港经典a毛片免费观看hd| 青青久久成人免费影院| 亚洲精品久久久久久中文传媒| 欧美在线 | 亚洲| 亚洲精品国产综合麻豆久久99| 嫖妓大龄熟妇正在播放| 亚洲中文字幕无码中文字| 久热国产vs视频在线观看| 秋秋影视午夜福利高清| 日韩精品久久久免费观看| 国内精品自在自线| 成人午夜看黄在线尤物成人| 天堂网www最新版官网| 日本免费一区二区三区视频观看| 少妇白浆高潮无码免费区| 又爽又黄又无遮挡的激情视频免费| 中文无码人妻影音先锋| 成人综合伊人五月婷久久| 日韩精品无码专区免费视频| h漫全彩纯肉无码网站| 沈阳45老熟女高潮喷水亮点| 日本高清视频www| 性xxxxx欧美极品少妇| 欧美精品videossex少妇| 欧美丰满熟妇xxxx| 国产在线拍揄自揄视频网试看| 人人爽人人爽人人片av亚洲| 巨爆乳无码视频在线观看|