在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse COP9 signalosome complex subunit 8 (Cops8)

Recombinant Mouse COP9 signalosome complex subunit 8 (Cops8)

  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8)
  • 貨號：
    CSB-YP844982MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8)
  • 貨號：
    CSB-EP844982MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8)
  • 貨號：
    CSB-EP844982MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8)
  • 貨號：
    CSB-BP844982MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8)
  • 貨號：
    CSB-MP844982MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cops8
  • Uniprot No.：
  • 別名：
    Cops8; Csn8COP9 signalosome complex subunit 8; SGN8; Signalosome subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-209
  • 氨基酸序列
    PVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins. PMID: 26383969
    2. Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim. PMID: 23840878
    3. CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart. PMID: 23873473
    4. Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration. PMID: 23689509
    5. Likely through regulating the expression of Rab7, Csn8/CSN plays a critical role in autophagosome maturation in myocardium. PMID: 21986281
    6. The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury. PMID: 20689553
    7. Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes PMID: 21051661
    8. involved in the transcriptional regulation of cell-specific gene expression PMID: 18706515

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲综合色自拍一区| 精品久久久久久久无码| 中文字幕亚洲无线码| 色偷一区国产精品| 曰本大码熟中文字幕| 忘忧草社区在线资源www| 亚洲国产成人久久综合| 18精品久久久无码午夜福利| 午夜私人成年影院| 日本少妇浓毛bbwbbwbbw| 少妇裸体性生交| av色综合久久天堂av色综合在 | 精品一卡二卡三卡| 电影久久久久久| 色午夜日本高清视频www| 久久人妻av一区二区软件| 中文字幕无码日韩专区免费| a狠狠久久蜜臀婷色中文网| 日韩不卡1卡2卡三卡2021免费| 少妇系列之白嫩人妻| 久久久综合香蕉尹人综合网| 免费看女人与公拘交酡过程| 特黄做受又粗又大又硬老头| 四虎精品成人免费视频| 亚洲aⅴ无码专区在线观看| 奇米影视色777四色在线首页| 久久久精品人妻一区二区三区蜜桃 | 亚洲精品国产美女久久久99 | 国产精品成人a区在线观看| 狠狠狠色丁香综合婷婷久久| 2020国产在线拍揄自揄视频| 国产98色在线 | 国产| 色伊人亚洲综合网站| 国产色情又大又粗又黄的电影| 亚洲 欧美 变态 另类 综合 | 亚洲中文字幕乱码电影| 茄子在线看片免费人成视频| 天天狠天天透天干天天怕∴| 2020久久香蕉国产线看观看| 午夜亚洲国产理论片中文飘花| av 日韩 人妻 黑人 综合 无码|