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  4. Recombinant Mouse COP9 signalosome complex subunit 5 (Cops5)

Recombinant Mouse COP9 signalosome complex subunit 5 (Cops5)

  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 5(Cops5)
  • 貨號：
    CSB-YP005792MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 5(Cops5)
  • 貨號：
    CSB-EP005792MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 5(Cops5)
  • 貨號：
    CSB-EP005792MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 5(Cops5)
  • 貨號：
    CSB-BP005792MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse COP9 signalosome complex subunit 5(Cops5)
  • 貨號：
    CSB-MP005792MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cops5
  • Uniprot No.：
  • 別名：
    Cops5; Csn5; Jab1; Kic2COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; EC 3.4.-.-; Jun activation domain-binding protein 1; Kip1 C-terminus-interacting protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-334
  • 氨基酸序列
    AASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INVA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
  • 基因功能參考文獻：
    1. Genetic deletion of Csn5 in Apoe(-/-) mice markedly exacerbated atherosclerotic lesion formation. PMID: 28292897
    2. COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills PMID: 25713139
    3. Jab1 is an essential regulator of early embryonic limb development. PMID: 24604556
    4. Lack of COPS5 in regenerating livers causes substantial replicative stress which triggers a cyclin-dependent kinase inhibitor(CDKN)2A genetic program leading to cell cycle arrest, polyploidy, and apoptosis. PMID: 24452456
    5. Jab1 may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting. PMID: 24344238
    6. Study demonstrates that Jab1 represses chondrocyte hypertrophy in vivo, likely in part by downregulating BMP signaling and Runx2 activity. PMID: 23203803
    7. Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 accumulation. PMID: 23357576
    8. CSN5 functions through CDK2 to control premature senescence in a novel way, depending on cyclin E in the cytoplasm. PMID: 23316279
    9. It was shown that disruption of CSN5 prevented the formation of tumors by p53-null cells that were transformed with an active form of Ras in subcutaneously injected mice. Depletion of CSN5 suppressed cell proliferation, and induced premature senescence. PMID: 23127558
    10. These findings identify JAB1 as an important factor in checkpoint control during early B cell development, as well as in fate decisions in mature Ag-primed B cells. PMID: 22327073
    11. Growth factor erv1-like (Gfer) inhibits the COP9 signalosome subunit jun activation-domain binding protein 1 (Jab1)-mediated degradation of the cyclin-dependent kinase inhibitor p27(kip1) to restrict proliferation of hematopoietic stem cells. PMID: 21346186
    12. the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 PMID: 21403132
    13. Jab1 is essential for efficient DNA repair and mechanistically link Jab1 to the maintenance of genome integrity and to cell survival. PMID: 20802511
    14. CSN5/Jab1 controls different events of the cell cycle PMID: 20974137
    15. Kip1 inhibits Jab1 mediated c-Jun dependent transcription PMID: 12119282
    16. the analysis of JAB1/CSN5 expression pattern in the mouse embryo PMID: 15183309
    17. Jab1 controls cell cycle progression and cell survival by regulating multiple cell cycle signaling pathways PMID: 15299027
    18. The small Jab1-containing subcomplex may be a novel mediator of anchorage and cell-cell contact-dependent signal transduction PMID: 15710389
    19. the interaction between Brn-2 and Jab1 may provide some insights into the understanding of neuronal development and neurodegenerative diseases PMID: 15911144
    20. Jab1 overexpression contributes to pancreatic cancer cell proliferation and survival. PMID: 17027978
    21. Macrophage migration inhibitory factor does not modulate co-activation of androgen receptor by Jab1/CSN5. PMID: 17786542
    22. the expression and function of JAB1 are critical for the proliferation and maintenance of hematopoietic progenitors PMID: 18667426

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  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族：
    Peptidase M67A family, CSN5 subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：


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