在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse CDK5 regulatory subunit-associated protein 2 (Cdk5rap2), partial

  • 中文名稱:
    Recombinant Mouse CDK5 regulatory subunit-associated protein 2(Cdk5rap2) ,partial
  • 貨號:
    CSB-YP815664MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse CDK5 regulatory subunit-associated protein 2(Cdk5rap2) ,partial
  • 貨號:
    CSB-EP815664MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse CDK5 regulatory subunit-associated protein 2(Cdk5rap2) ,partial
  • 貨號:
    CSB-EP815664MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse CDK5 regulatory subunit-associated protein 2(Cdk5rap2) ,partial
  • 貨號:
    CSB-BP815664MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse CDK5 regulatory subunit-associated protein 2(Cdk5rap2) ,partial
  • 貨號:
    CSB-MP815664MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cdk5rap2; Kiaa1633CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear.
  • 基因功能參考文獻:
    1. We highlight that infertility in Cdk5rap2 mutant mice is secondary to a lack of spermatogenic cells in adult mice as a result of an early developmental defect in the germ cells through mitotic delay, prolonged cell cycle, and apoptosis. PMID: 28162995
    2. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms PMID: 26550838
    3. this study revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice. PMID: 26322982
    4. In Cdk5rap2-depleted neural embryonic stem cells there is an increase in cell death in differentiating cells. PMID: 25942099
    5. Mouse expression pattern of CDK5RAP2 is similar to that seen in humans and is in concordance with pathology suggested by neuroimaging studies in humans and mouse PMID: 22806269
    6. This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A. PMID: 22875938
    7. These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication. PMID: 20627074
    8. Cdk5rap2 is highly expressed in the neural progenitor pool and its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation PMID: 20471352
    9. The an mutation is a genomic inversion of exon 4 of Cdk5rap2, resulting in an in-frame deletion of exon 4 from the mRNA. Cdk5rap2(an/an) neuronal precursors exit the cell cycle prematurely and many undergo apoptosis. PMID: 20460369

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm.
  • 組織特異性:
    Expressed in testis, thymus, heart and brain.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲色欲久久久久综合网| 粗大的内捧猛烈进出| 国产精品99久久精品爆乳| 国产精品一区二区av麻豆| 日韩精品一区二区大桥未久| 免费观看又色又爽又湿的软件| 污污污www精品国产网站| 国产精品毛片av在线看| 国产精品女人呻吟在线观看| 日本又黄又爽又色又刺激的视频 | 国精产品999国精产品官网| 午夜精品久久久久久久久久久久| 日本熟妇浓密毛毛多| 老女老肥熟国产在线视频| 欧美另类videossexo高潮| 熟女无套内射线观56| 国精品人妻无码一区免费视频电影 | 夜夜嗨av一区二区三区| 无码少妇一区二区三区芒果 | 2021久久最新国产精品| 欧美三根一起进三p| 无人区码一码二码w358cc| 欧美一性一乱一交一免费视频| 日本另类αv欧美另类aⅴ| 狠狠躁夜夜躁人人爽天天天天97| 色又黄又爽18禁免费视频| 无码三级中文字幕在线观看| 国产日韩欧美一区二区东京热| 韩国精品福利一区二区三区| 五月激激激综合网亚洲| 人妻熟女一区二区aⅴ清水理纱 | 精品国产一区二区三区无码| 色综合99久久久无码国产精品| 人妻熟女av一区二区三区| 久久九九国产精品怡红院| 国产精品极品美女自在线观看免费| 国产精品一区波多野结衣| 久久天天躁夜夜躁狠狠躁| ass日本丰满熟妇pics| 久久影视久久午夜| 九九久久精品国产免费看小说|