在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse CD63 antigen (Cd63), partial

In Stock
  • 中文名稱:
    Recombinant Mouse CD63 antigen(Cd63) ,partial
  • 貨號:
    CSB-EP004950MOe0
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    Cd63
  • Uniprot No.:
  • 別名:
    Cd63CD63 antigen; CD antigen CD63
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Extracellular Domain
  • 來源:
    E.coli
  • 分子量:
    38.5kDa
  • 表達(dá)區(qū)域:
    103-203aa
  • 氨基酸序列
    AGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal GST-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
  • 基因功能參考文獻(xiàn):
    1. In renal proximal tubules, CD63 determines the insertion of OCT2 into the proper membrane domain and mediates transporter regulation by trafficking processes. PMID: 28031320
    2. TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells. PMID: 27506299
    3. The Muted protein is important for the steady-state level of CD63. PMID: 27531610
    4. Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity. PMID: 25354204
    5. These findings identify CD63 as an important component of allergic inflammation. PMID: 23945142
    6. CD63 serves to bridge between beta1 integrin and VEGFR2 because CD63 silencing disrupted VEGFR2-beta1 integrin complex formation identified using proximity ligation assay PMID: 23632027
    7. Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis. PMID: 21962903
    8. Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin. PMID: 21803846
    9. CXCR4 can be downregulated on activated B cells by IL-21-induced endocytosis and CD63-mediated endosomal recruitment. PMID: 21270405
    10. The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII is targeted to lysosomes. PMID: 21041449
    11. CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7. PMID: 20236428
    12. CD63 is recruited to already-budded Weibel-Palade bodies by an AP-3-dependent route PMID: 16683915
    13. Upon phagocytosis of Cryptococcus neoformans and polystyrene beads, CD63 was recruited selectively to C. neoformans-containing phagosomes in a MyD88-independent acidification-dependent manner PMID: 17043215
    14. protein region defined by amino acid residues 103-205 for CD63 interacts with amelogenin PMID: 17708745
    15. CD63 knockout mice show an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content. PMID: 19075008
    16. the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1 PMID: 19079288

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface.
  • 蛋白家族:
    Tetraspanin (TM4SF) family
  • 組織特異性:
    Ubiquitous. Strongly expressed in kidney. Detected in spleen, bone marrow, peripheral blood mononuclear cells and macrophages.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 青青国产揄拍视频| 2019国产品在线视频| 真人无码作爱免费视频| 欧美国产激情18| 欧美日韩精品无码一本二本三本色| 亚洲精品成人福利网站| 无码中文字幕乱在线观看| 麻豆高清免费国产一区| 成年女人免费v片| 国产成人啪精品视频免费视频| 国产亚洲综合区成人国产系列| 丰满女人又爽又紧又丰满| 性无码免费一区二区三区在线| 久久亚洲中文无码咪咪爱| 国产美女久久久亚洲综合| 黑鬼大战白妞高潮喷白浆| 老湿机69福利区18禁网站| 99热这里只有精品国产免费免费 | 少妇愉情理伦片高潮日本| 国产毛片毛多水多的特级毛片| 国产亚洲日韩在线a不卡| 亚洲欧美国产精品久久| 图片区小说区激情区偷拍区| 国产精品亚洲а∨怡红院| 免费无码又爽又刺激聊天app| 女人张开腿让男人桶个爽| 久青草国产97香蕉在线影院| 国自产拍偷拍精品啪啪av| 国产av一区二区三区| 国产精品99久久免费黑人人妻| 国产薄丝脚交视频在线观看| 综合 欧美 小说 另类 图| 国产精品揄拍100视频| 亚洲日韩一页精品发布| 狠人干练合综合网| 人妻无码中字在线a| 少妇人妻邻居| 国产精品成人嫩草影院| 小污女导航福利入口| 亚洲精品夜夜夜| 2022久久国产精品免费热麻豆|