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  4. Recombinant Mouse CD109 antigen (Cd109), partial

Recombinant Mouse CD109 antigen (Cd109), partial

  • 中文名稱：
    Recombinant Mouse CD109 antigen(Cd109) ,partial
  • 貨號：
    CSB-YP837143MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse CD109 antigen(Cd109) ,partial
  • 貨號：
    CSB-EP837143MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse CD109 antigen(Cd109) ,partial
  • 貨號：
    CSB-BP837143MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse CD109 antigen(Cd109) ,partial
  • 貨號：
    CSB-MP837143MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cd109
  • Uniprot No.：
  • 別名：
    Cd109CD109 antigen; GPI-anchored alpha-2 macroglobulin-related protein; CD antigen CD109
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Modulates negatively TGFB1 signaling in keratinocytes.
  • 基因功能參考文獻(xiàn)：
    1. Results indicate that CD109 deficiency induces a high-turnover, osteoporosis-like phenotype, which suggests that CD109 plays a role in bone metabolism in vivo. PMID: 29767469
    2. CD109 deficiency suppresses skin tumorigenesis by enhancing TGF-beta/Smad/Nrf2 pathway activity and decreasing the mutation frequency of the H-ras gene. PMID: 27756876
    3. High expression of CD109 in brain tumor stem cells is involved in glioma progression. PMID: 28888050
    4. platelet and endothelial GARP are not important in hemostasis and thrombosis in mice PMID: 28278197
    5. Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis PMID: 28191885
    6. CD109 differentially regulates TGF-beta-induced ALK1-Smad1/5 versus ALK5-Smad2/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism PMID: 27866969
    7. the GARP/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 needed for induction of pTreg cells during the process of oral tolerance. PMID: 27062243
    8. GP96 serves as an essential chaperone for the cell-surface protein glycoprotein A repetitions predominant (GARP), which is a docking receptor for latent membrane-associated TGF-beta (mLTGF-beta). PMID: 25607841
    9. CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing PMID: 24815824
    10. CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109. PMID: 24400073
    11. CD109 might be an important regulator of osteoclastogenesis. PMID: 23593435
    12. findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo. PMID: 23438099
    13. Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-beta1/GARP complex on their cell surface rather than by secreted latent TGF-beta1. PMID: 23645881
    14. CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma. PMID: 23436317
    15. CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3. PMID: 22846721

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 數(shù)據(jù)庫鏈接：


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