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  4. Recombinant Mouse BTB/POZ domain-containing protein KCTD12 (Kctd12)

Recombinant Mouse BTB/POZ domain-containing protein KCTD12 (Kctd12)

  • 中文名稱：
    小鼠Kctd12重組蛋白
  • 貨號：
    CSB-YP751053MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kctd12重組蛋白
  • 貨號：
    CSB-EP751053MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kctd12重組蛋白
  • 貨號：
    CSB-EP751053MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kctd12重組蛋白
  • 貨號：
    CSB-BP751053MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kctd12重組蛋白
  • 貨號：
    CSB-MP751053MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kctd12
  • Uniprot No.：
  • 別名：
    Kctd12; Pfet1BTB/POZ domain-containing protein KCTD12; Pfetin; Predominantly fetal expressed T1 domain
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-327
  • 氨基酸序列
    ALADSARGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFFFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PPHSRRGVHK EGSLGDELLP LGYAEPEPQE GASAGAPSPT LELASRSPSG GAAGPLLTPS QSLDGSRRSG YITIGYRGSY TIGRDAQADA KFRRVARITV CGKTSLAKEV FGDTLNESRD PDRPPERYTS RYYLKFNFLE QAFDKLSESG FHMVACSSTG TCAFASSTDQ SEDKIWTSYT EYVFCRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
  • 基因功能參考文獻：
    1. KCTD12 is involved in determining phenotypes of emotionality, behavioral activity and neuronal excitability. PMID: 25689571
    2. Serine-892 phosphorylation in GABAB receptor rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization in neurons. PMID: 25065880
    3. the up-regulation of functional GABA(B) receptors at the neuronal plasma membrane is an additional physiological role of the auxiliary subunit KCTD12. PMID: 23843457
    4. new gene encoding 327 amino acids in mouse contains a voltage-gated potassium (K+) channel tetramerization (T1) domain. PMID: 15357420
  • 亞細胞定位：
    Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Colocalizes with GABRB1.
  • 組織特異性：
    Expressed in the brain, mainly in the hippocampus and cerebellum.
  • 數據庫鏈接：

    KEGG: mmu:239217

    UniGene: Mm.246466



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