在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse BPI fold-containing family A member 1 (Bpifa1)

  • 中文名稱:
    Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
  • 貨號:
    CSB-YP018213MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
  • 貨號:
    CSB-EP018213MO
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
  • 貨號:
    CSB-EP018213MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
  • 貨號:
    CSB-BP018213MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
  • 貨號:
    CSB-MP018213MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Bpifa1
  • Uniprot No.:
  • 別名:
    Bpifa1; Plunc; Splunc1; BPI fold-containing family A member 1; Palate lung and nasal epithelium clone protein
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    20-278
  • 氨基酸序列
    Q LAGLPLPLGQ GPPLPLNQGP PLPLNQGQLL PLAQGLPLAV SPALPSNPTD LLAGKFTDAL SGGLLSGGLL GILENIPLLD VIKSGGGNSN GLVGGLLGKL TSSVPLLNNI LDIKITDPQL LELGLVQSPD GHRLYVTIPL GLTLNVNMPV VGSLLQLAVK LNITAEVLAV KDNQGRIHLV LGDCTHSPGS LKISLLNGVT PVQSFLDNLT GILTKVLPEL IQGKVCPLVN GILSGLDVTL VHNIAELLIH GLQFVIKV
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
  • 基因功能參考文獻:
    1. Bpifa1-deficient (Bpifa1-/-) mice exhibited spontaneous airway hyperresponsiveness and that excised tracheas from Bpifa1+/+ but not Bpifa1-/- mice were capable of reducing airway smooth muscle contraction. PMID: 28165446
    2. this study shows that BPIFA1/SPLUNC1 restricts influenza A virus infection PMID: 28513596
    3. SPLUNC1-knockout mice was established in a LPS-induced acute lung injury (ALI) mouse model to study the anti-inflammatory effect of SPLUNC1. Results found that SPLUNC1 deficiency upregulated levels of ALI-related cytokines leading to more severe lung injury after LPS injection. Moreover, further data discovered that the presence of SPLUNC1 can suppress the recruitment of CD11b+Gr-1+ MDSCs to the spleen in LPS-induced ALI. PMID: 29115527
    4. Loss of Splunc1 predisposes mice to the development of otitis media. PMID: 25765466
    5. SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection. PMID: 23499554
    6. Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function. PMID: 22986921
    7. SPLUNC1 is present at high concentrations in murine airways under basal conditions, whereas it is suppressed by low-level environmental pathogen-associated molecular patterns and inflammatory signals. PMID: 23470624
    8. SPLUNC1 KO mice demonstrated significantly higher numbers of eosinophils in the lung after OVA challenges than did wild-type mice. PMID: 22499853
    9. Our findings demonstrate a critical in vivo role of SPLUNC1 in host defense against bacterial infection PMID: 21514430
    10. Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production. PMID: 21054862
    11. splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia PMID: 15028288
    12. SPLUNC1 protein decreases Mycoplasma pneumoniae (Mp) levels and inhibits epithelial IL-8 production induced by Mp-derived lipoproteins. PMID: 17785838

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
  • 蛋白家族:
    BPI/LBP/Plunc superfamily, Plunc family
  • 組織特異性:
    Detected in airway epithelia (trachea and lung) and in bronchoalveolar fluid (at protein level). Upper airways, nasopharyngeal epithelium and thymus. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiol
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 无码专区无码专区视频网址| 99久久精品国产免费| 青青草国产精品一区二区| 国产日韩在线时看高清视频 | 欧洲人妻丰满av无码久久不卡| 日本丰满岳乱妇在线观看| 亚洲一线二线三线写真| 色翁荡熄又大又硬又粗又动态图| 国产福利一区二区麻豆| 女人被狂爆到高潮免费视频| 玩弄人妻少妇精品视频| 午夜福利92国语| 无码日韩人妻av一区免费| 亚洲国产精品不卡av在线| 国产激情精品一区二区三区 | 天堂va蜜桃一区二区三区| 影音先锋男人av鲁色资源网| 亚洲欧美中文高清在线专区 | 国产乱子伦三级在线播放| 国产女人被狂躁到高潮小说| 午夜不卡无码中文字幕影院| 四虎国产精品永久在线无码| 国产一卡三卡四卡无卡精品 | 久久精品国产清高在天天线| 国产性―交―乱―色―情人| 在线观看国产精品电影| 国产精品爽爽久久久久久| 亚洲一区在线观看尤物| 中文字幕+乱码+中文字幕一区| 亚洲制服丝袜av一区二区三区| 国内精品国产三级国产av| 国产精品丝袜黑色高跟鞋| 国产在线精品99一区不卡| 国产69精品久久久久孕妇| 重口sm一区二区三区视频| 精品人妻一区二区三区四区| 中文字幕人乱码中文字幕| 亚洲丁香婷婷久久一区二区| 国产精品高清视亚洲中文| 四虎成人精品国产永久免费无码| 51久久国产露脸精品国产|