在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Anterior gradient protein 2 homolog (Agr2)

  • 貨號:
    CSB-YP001458MO
  • 規格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Agr2
  • Uniprot No.:
  • 別名:
    Protein Gob-4 Secreted cement gland protein XAG-2 homolog
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Yeast
  • 分子量:
    19.9 kDa
  • 表達區域:
    21-175aa
  • 氨基酸序列
    KDTTVKSGAKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALLYDNMKKALKLLKTEL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    25-35 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
  • 基因功能參考文獻:
    1. AGR2 accelerates skin wound healing through regulation of cell migration. PMID: 28665039
    2. AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation. PMID: 27941872
    3. impact of AGR2 expression and EGFR signaling on tissue regeneration PMID: 27764193
    4. EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression. PMID: 25666625
    5. AGR2 has both intracellular and extracellular effects in the intestine PMID: 25111734
    6. Results indicate that DNA methylation within the AGR2 promoter modulates more aggressive cancer cell phenotypes. PMID: 24920423
    7. It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13. PMID: 23392704
    8. Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells. PMID: 23209296
    9. Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells. PMID: 22819674
    10. Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). PMID: 22675208
    11. studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease PMID: 20025862
    12. AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. PMID: 18199544
    13. Overexpression of Agr2 is associated with asthma. PMID: 19028979
    14. AGR2 is a unique member of the protein disulfide isomerase family, with a specialized and nonredundant role in intestinal mucus production PMID: 19359471

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Endoplasmic reticulum.
  • 蛋白家族:
    AGR family
  • 組織特異性:
    Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach.
  • 數據庫鏈接:


主站蜘蛛池模板: 丰满多毛的陰户视频| 东北女人毛多水多牲交视频| 日本在线高清不卡免费播放| 国产精品无码久久av不卡| 中文无码日韩欧av影视| 国产精品亚洲一区二区| 无码人妻精品一区二区三区东京热 | 亚洲性猛交xxxx| 色妞色视频一区二区三区四区| 人妻少妇精品专区性色av| 成人免费无码不卡毛片视频| 内射人妻少妇无码一本一道| 另类内射国产在线| 色欲久久人妻内射| 国产成人亚洲精品无码电影| 婷婷激情综合色五月久久竹菊影视| 欧美性xxxxx极品少妇直播| 国产精品兄妹在线观看麻豆| 无码国产成人午夜视频在线播放| 超级大爆乳奶牛被调教出奶水| 国产疯狂伦交大片| 欧美巨鞭大战丰满少妇| 亚洲成色综合网站在线| 浪货趴办公桌~h揉秘书电影| 色偷偷色噜噜狠狠成人免费视频| 日本大胆欧美人术艺术| 免费观看国产小粉嫩喷水| 18无码粉嫩小泬无套在线观看 | 国产福利一区二区三区在线视频| 欧美激情在线播放| 老司机导航亚洲精品导航| 久久久久久综合岛国免费观看| 国产又滑又嫩又白| 天天做天天爱天天综合网2021| 色舞月亚洲综合一区二区| 一本久久精品一区二区| 99热久久这里只有精品| 国产亚洲精品美女在线| 2020国产在线拍揄自揄视频| 中文字幕无码一区二区免费| 色 成人 亚洲|