在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Anterior gradient protein 2 homolog (Agr2)

  • 貨號:
    CSB-YP001458MO
  • 規格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Agr2
  • Uniprot No.:
  • 別名:
    Protein Gob-4 Secreted cement gland protein XAG-2 homolog
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Yeast
  • 分子量:
    19.9 kDa
  • 表達區域:
    21-175aa
  • 氨基酸序列
    KDTTVKSGAKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALLYDNMKKALKLLKTEL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    25-35 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
  • 基因功能參考文獻:
    1. AGR2 accelerates skin wound healing through regulation of cell migration. PMID: 28665039
    2. AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation. PMID: 27941872
    3. impact of AGR2 expression and EGFR signaling on tissue regeneration PMID: 27764193
    4. EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression. PMID: 25666625
    5. AGR2 has both intracellular and extracellular effects in the intestine PMID: 25111734
    6. Results indicate that DNA methylation within the AGR2 promoter modulates more aggressive cancer cell phenotypes. PMID: 24920423
    7. It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13. PMID: 23392704
    8. Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells. PMID: 23209296
    9. Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells. PMID: 22819674
    10. Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). PMID: 22675208
    11. studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease PMID: 20025862
    12. AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. PMID: 18199544
    13. Overexpression of Agr2 is associated with asthma. PMID: 19028979
    14. AGR2 is a unique member of the protein disulfide isomerase family, with a specialized and nonredundant role in intestinal mucus production PMID: 19359471

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Endoplasmic reticulum.
  • 蛋白家族:
    AGR family
  • 組織特異性:
    Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach.
  • 數據庫鏈接:


主站蜘蛛池模板: 丁香婷婷激情综合俺也去| 亚洲午夜无码久久yy6080| 国内熟妇人妻色在线视频| 中文字幕乱码一区二区免费| 亚洲欧美日产综合在线| 中文字幕资源网| 国产精品激情av久久久青桔| 国产精品兄妹在线观看麻豆| 色情久久久av熟女人妻网站| 久久人妻国产精品| 国产日韩av一区二区三区五区| 在线观看片a免费不卡观看| 欧美老妇与禽交| 99精品久久99久久久久| 亚洲欧美日韩成人综合网| 国产粉嫩嫩00在线正在播放| 国产成熟女人性满足视频| 熟妇高潮喷沈阳45熟妇高潮喷| 天天做天天爱夜夜爽| 国产综合有码无码视频在线 | 男人和女人做爽爽视频| 色婷婷狠狠久久综合五月| 免费全部高h视频无码| 少妇熟女久久综合网色欲| 香蕉久久精品日日躁夜夜躁夏| 国产精品人妻一区夜夜爱| 大香线蕉伊人精品超碰| 精品无码成人网站久久久久久 | 亚洲狠狠做深爱婷婷影院| 极品美女扒开粉嫩小泬| 人人妻人人爽人人做夜欢视频| 欧美极p品少妇的xxxxx| 国产成人综合久久免费| 国产精品爽爽久久久久久| 国产在线 | 欧洲| 亚洲国产精品嫩草影院永久| 18级成人毛片免费观看| 国产亚洲精品久久久久久青梅| 中文字幕亚洲乱码熟女一区二区| 日本wv一本一道久久香蕉| 大胸美女被吃奶爽死视频|