在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Anoctamin-6 (Ano6), partial

Recombinant Mouse Anoctamin-6 (Ano6), partial

  • 中文名稱：
    Recombinant Mouse Anoctamin-6(Ano6) ,partial
  • 貨號：
    CSB-YP750831MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Anoctamin-6(Ano6) ,partial
  • 貨號：
    CSB-EP750831MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Anoctamin-6(Ano6) ,partial
  • 貨號：
    CSB-EP750831MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Anoctamin-6(Ano6) ,partial
  • 貨號：
    CSB-BP750831MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Anoctamin-6(Ano6) ,partial
  • 貨號：
    CSB-MP750831MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ano6; Tmem16fAnoctamin-6; Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
  • 基因功能參考文獻：
    1. TMEM16F knockout did not affect Ca2+ signaling and Ca2+-activated whole cell currents in podocytes. TMEM16F shows little effect on basal properties of podocytes and does not appear to be essential for renal function. PMID: 29912162
    2. TMEM16F interaction with phosphatidylinositol-(4, 5)-bisphosphate works synergistically with membrane depolarization to facilitate Ca(2+)-gating of TMEM16F. PMID: 29382763
    3. TMEM16F is an essential component of the microglial response to injury and suggest the importance of microglial phagocytosis in the pathogenesis of neuropathic pain. PMID: 27332874
    4. The present data demonstrate the activation of ANO6 during necroptosis, which, however, is not essential for cell death. PMID: 27535660
    5. TMEM16F deficiency results in sustained signaling and augmented T cell activation. PMID: 27810927
    6. Platelet TMEM16F activity contributes significantly to hemostasis and thrombosis but not cerebral thromboinflammation. PMID: 27634832
    7. ANO6 produces volume-regulated anion currents and controls cell volume in four unrelated cell types. PMID: 26438191
    8. deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID: 26481309
    9. Although broadly expressed, Ano6 has no role in intestinal cholinergic Cl- secretion. PMID: 24974903
    10. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID: 25651887
    11. TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. PMID: 26417084
    12. Ano6 and Ano2 proteins co-localize in the ciliary membrane microdomains, which indicates a role for Ano6 in olfactory signaling. PMID: 25500808
    13. human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
    14. Ano6 plays an essential role in C2C12 myoblast proliferation PMID: 24663380
    15. The mTMEM16F-associated ICl,Ca was abolished in one mutant of the putative pore region (R592E. PMID: 23630341
    16. In primary Ano6(-/-) osteoblasts, mineralization is delayed, indicating a cell autonomous function of Ano6. PMID: 22936354
    17. TMEM16F forms a SCAN channel with considerable Ca2+ selectivity-an unprecedented finding of a cation channel as a closely related family member of anion channels; loss of TMEM16F function greatly reduced the propensity to thrombosis. PMID: 23021219
    18. Data show the expression of Tmem16f during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems. PMID: 18729231
    19. during mouse cephalic development: detected in subventricular zone and differentiating fields, in rostral spinal cord motor neuron area, stria vascularis,in submandibular autonomic ganglia, in palate, tooth and tongue, and in osteoblasts and chondrocytes PMID: 19059364

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anoctamin family
  • 組織特異性：
    Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 草草影院发布页| 免费观看一区二区三区| 欧美与黑人午夜性猛交久久久| aa片在线观看视频在线播放| 色综合网天天综合色中文| 日本少妇浓毛bbwbbwbbw| 奶头好大狂揉60分钟视频| 蜜桃av抽搐高潮一区二区 | 亚洲日本va午夜中文字幕久久| 欧美乱人伦视频在线| 亚洲精品久久久久午夜福禁果tⅴ| 欧美黑人添添高潮a片www| 丝袜美腿丝袜亚洲综合| 插插插精品亚洲一区| 国产精品美女久久久网站 | 92国产精品午夜福利无毒不卡| 少妇又紧又深又湿又爽视频| 国内露脸中年夫妇交换| 免费国产午夜理论片不卡| 久久久国产99久久国产久一| 日产精品久久久一区二区| 极品少妇hdxx麻豆hdxx| 国产性―交―乱―色―情人| 天堂在线.www天堂在线资源| 国产激情久久久久久熟女老人| 亚洲动漫精品无码av天堂| 2021年精品国产福利在线| 久碰人妻人妻人妻人妻人掠| 久久精品国产99国产精品导航| av高清无码 在线播放| 国产作爱视频免费播放| 久久久亚洲欧洲日产国码是av| a国产在线v的不卡视频| 撕开奶罩揉吃奶高潮av在线观看| 精品乱子伦一区二区三区| k频道国产在线观看| 寂寞骚妇被后入式爆草抓爆 | 欧美奶涨边摸边做爰视频| 久久人人爽人人爽人人片dvd| 精品国产一区二区三区av色诱| 人妻互换一二三区激情视频 |