在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse ATP-sensitive inward rectifier potassium channel 8 (Kcnj8), partial

Recombinant Mouse ATP-sensitive inward rectifier potassium channel 8 (Kcnj8), partial

  • 中文名稱：
    小鼠Kcnj8重組蛋白
  • 貨號：
    CSB-YP012060MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kcnj8重組蛋白
  • 貨號：
    CSB-EP012060MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kcnj8重組蛋白
  • 貨號：
    CSB-EP012060MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kcnj8重組蛋白
  • 貨號：
    CSB-BP012060MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kcnj8重組蛋白
  • 貨號：
    CSB-MP012060MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Kcnj8; ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+ channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
  • 基因功能參考文獻：
    1. Endotoxemia increases pulmonary Kir6.1 gene and protein expression. PMID: 29433570
    2. miR-20 may regulate myocardiac ischemia by targeting KATP subunit Kir6.1 to accelerate the cell apoptosis. PMID: 28786072
    3. S422L mutation in KCNJ8 gene is not a direct cause of J wave syndrome. PMID: 28928055
    4. Together, these results implicate the incorporation of native Kir6.1 subunits into pancreatic KATP channels and a contributory role for these subunits in the control of insulin secretion. PMID: 27956473
    5. data support the existence of an endothelial KATP channel that contains Kir6.1, is involved in vascular reactivity in the coronary circulation, and has a protective role in ischemia reperfusion. PMID: 28893911
    6. Similar to previous results in Kir6.1(-/-) myocytes, Kir6.1 gain of function myocytes demonstrate resistance (less volume derangement) to stress of cardioplegia. PMID: 27884343
    7. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. PMID: 27247394
    8. Kcnj8 mutation is responsible of heart conduction abnormalities in Cantu syndrome. PMID: 26142302
    9. our study demonstrated that exercise training up-regulated Kir6.1, improved tissue oxygenation recovery, and protected the heart against I/R injury PMID: 25474642
    10. Results suggest that the vascular KATP channel Kcnj8 is organ protective in diabetic conditions. PMID: 25825210
    11. The absence of Kir6.1 does not affect the contractile properties of myocytes during stress, suggesting the absence of Kir6.1 improves myocyte tolerance to stress via an unknown mechanism. PMID: 25872691
    12. Sulfhydration of SUR2B subunit modifies tyrosine nitration of Kir6.1 subunit within the KATP channel complex. PMID: 25552582
    13. Kir6.1 underlies the vascular smooth muscle KATP channel and has a key role in vascular reactivity and blood pressure control. PMID: 24914196
    14. Native K(ATP) channels in mouse vas deferens myocytes are a heterocomplex of K(IR)6.1 channels and SUR2B subunits. PMID: 24117345
    15. Kir6.1 knockdown exacerbates cerebral ischemia reperfusion-induced brain damage. PMID: 23663330
    16. A possible partnership between Cx43 and Kir6.1 will help in better understanding their roles in ischemia/hypoxia preconditioning. PMID: 22960107
    17. K(ATP) channel deregulation can have a critical impact on innate antiviral immunity in the heart. PMID: 21719711
    18. gene disruption causes prinzmetal angina in knockout mice PMID: 11984590
    19. Kir 6.1 gene expression was upregulated by almost 22-fold, whereas SUR2B was downregulated by threefold after inflammation. Decreased motility of colon during inflammation may be associated with changes in transcriptional regulation of Kir 6.1 and SUR2B. PMID: 14962845
    20. Kir6.1-containing K(ATP) channel, by coupling vasoreactivity with metabolic demand, provides a vital feedback element for cardiovascular tolerance in endotoxic shock. PMID: 17077304
    21. Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. PMID: 17883401
    22. Study identified a profound susceptibility to infection phenotype due to a null allele of Kcnj8, encoding Kir6.1, a protein that combines with SUR2 to form an ATP-sensitive potassium channel (K(ATP)) expressed in coronary artery. PMID: 18026101
    23. The data suggest it is premature to assign Kir6.1 a role in mitoK(ATP) on the basis of immunoreactivity alone. PMID: 18068667
    24. SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts. PMID: 19166858

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ8 subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 精品久久国产综合婷婷五月| 污污内射久久一区二区欧美日韩| av无码精品一区二区三区| 人妻av综合天堂一区| 成人小说亚洲一区二区三区| 日韩va中文字幕无码电影| 色综合色综合久久综合频道88| 日日做夜狠狠爱欧美黑人| 在线观看国产午夜福利片| 丰满少妇aaaaaa爰片毛片| 精品国产成人高清在线观看| 精品97国产免费人成视频| 女人高潮被爽到呻吟在线观看| 免费无码av一区二区| 午夜成人爽爽爽视频在线观看 | 精品国产天堂综合一区在线| 欧美日韩中文国产一区发布 | 自拍性旺盛老熟女| 日韩一区二区三区精品| 国产日韩av无码免费一区二区| 蜜臀色欲av在线播放国产日韩| 99爱在线精品视频免费观看| 亚洲午夜高清国产拍| 国产亚洲欧美精品永久| 成熟女人毛片www免费版在线| 麻批好紧日起要舒服死了| 人人人爽人人爽人人av| 人妻无码手机在线中文| 男女18禁啪啪无遮挡激烈网站| 亚洲18禁私人影院| 欧美性生交xxxxx久久久| 8x福利精品第一导航| 无码人妻丝袜视频在线播免费| 日本国产制服丝袜一区| 国产激情艳情在线看视频 | 久久久女人与动物群交毛片| 亚洲国产人在线播放首页| 国产精品视频| 国产sm主人调教女m视频| 中出あ人妻熟女中文字幕| 永久免费精品成人网站|