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  4. Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (Plcb2), partial

Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (Plcb2), partial

  • 中文名稱：
    小鼠Plcb2重組蛋白
  • 貨號：
    CSB-YP018127MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Plcb2重組蛋白
  • 貨號：
    CSB-EP018127MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Plcb2重組蛋白
  • 貨號：
    CSB-EP018127MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Plcb2重組蛋白
  • 貨號：
    CSB-BP018127MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Plcb2重組蛋白
  • 貨號：
    CSB-MP018127MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; EC 3.1.4.11; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
  • 基因功能參考文獻：
    1. Data suggest the a decrease in migration of hematopoietic stem progenitor cells (HSPCs) can be explained by impaired calcium release in phospholipase C-beta2 (PLC-beta2) knockout (KO) mice and a high baseline level of heme oxygenase 1 (HO-1), an enzyme that negatively regulates cell migration. PMID: 27704316
    2. tristetraprolin is not involved in LPS-mediated destabilization of PLCbeta-2 mRNA in macrophages PMID: 28124257
    3. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. PMID: 22728827
    4. A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. PMID: 22172670
    5. The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells. PMID: 20871625
    6. Taurine supplementation increases insulin secretion, favouring both influx and internal mobilisation of Ca2+; these effects seem to involve multiple pathways. PMID: 20591207
    7. suppression of PLCbeta2 plays an important role in switching M1 macrophages into an M2-like state. PMID: 19850892
    8. Expression of Plcb2 was studied in a cell line during myoblast differentiation. PMID: 15174099
    9. both PLCbeta2/beta3 and PI3Kgamma play vital roles in platelet cytoskeletal dynamics PMID: 15705797
    10. Expesssed by ssensory cells in the olfactory neuroepithelium. PMID: 15926917
    11. confirm role for PLCbeta2 in taste responsiveness to sucrose and to low- to midrange concentrations of quinine and denatonium, and suggest that higher concentrations of the latter two compounds can engage a PLCbeta2-independent taste transduction pathway PMID: 16135743
    12. loss of PLCbeta2 and PLCbeta3 significantly impaired T cell migration. PMID: 17675482
    13. Transgenic PLCb2-GFP mice label taste bud cells and olfactory microvillar cells. Immune cells not examined. PMID: 16394244
    14. Essential sensory transduction component from taste GPCRs for sweet, bitter, umami tastes PMID: 12581520

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