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  4. Recombinant Macaca mulatta Mediator of DNA damage checkpoint protein 1 (MDC1), partial

Recombinant Macaca mulatta Mediator of DNA damage checkpoint protein 1 (MDC1), partial

  • 中文名稱：
    獼猴MDC1重組蛋白
  • 貨號：
    CSB-YP725909MOW
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    獼猴MDC1重組蛋白
  • 貨號：
    CSB-EP725909MOW
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    獼猴MDC1重組蛋白
  • 貨號：
    CSB-EP725909MOW-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    獼猴MDC1重組蛋白
  • 貨號：
    CSB-BP725909MOW
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    獼猴MDC1重組蛋白
  • 貨號：
    CSB-MP725909MOW
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MDC1
  • Uniprot No.：
  • 別名：
    MDC1; Mediator of DNA damage checkpoint protein 1
  • 種屬：
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 數據庫鏈接：


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