在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca fascicularis Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1), partial

  • 中文名稱:
    獼猴EIF2AK1重組蛋白
  • 貨號:
    CSB-YP007510MOV
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    獼猴EIF2AK1重組蛋白
  • 貨號:
    CSB-EP007510MOV
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    獼猴EIF2AK1重組蛋白
  • 貨號:
    CSB-EP007510MOV-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    獼猴EIF2AK1重組蛋白
  • 貨號:
    CSB-BP007510MOV
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    獼猴EIF2AK1重組蛋白
  • 貨號:
    CSB-MP007510MOV
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    EIF2AK1; QtsA-12694Eukaryotic translation initiation factor 2-alpha kinase 1; EC 2.7.11.1; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Hemin-sensitive initiation factor 2-alpha kinase
  • 種屬:
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions. Also activates the ISR in response to mitochondrial dysHRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming.
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
  • 數據庫鏈接:

    KEGG: mcf:101865823

    UniGene: Mfa.1333



主站蜘蛛池模板: 亚洲精品第一国产综合国服瑶 | 久久性色av亚洲电影| 日日碰狠狠添天天爽无码 | 麻豆日产精品卡2卡3卡4卡5卡 | 久久爱www人成狠狠爱综合网| 亚洲日韩中文字幕在线不卡最新| 大黑人交xxxx18视频| 人妻去按摩店被黑人按中出| 日产电影一区二区三区| 国产日产欧产精品精品| 亚洲中文欧美在线视频| 亚洲男人a在天堂线一区| 天天摸天天做天天爽水多| 国产成人无码18禁午夜福利p| 亚洲乱亚洲乱妇中文影视| 午夜性色福利在线视频福利| 国产作爱激烈叫床视频| 国产网红无码精品视频| 欧美性猛交xxxx乱大交极品| 久久久久精品无码一区二区三区| 丝袜足控一区二区三区| av免费网址在线观看| 天天爽夜夜爽夜夜爽| 色综久久综合桃花网国产精品| 午夜福利免费0948视频| 日日天干夜夜狠狠爱| 成人aa免费视频在线播放| 无码国产玉足脚交极品网站| 亚洲色爱图小说专区| 巨胸不知火舞露双奶头无遮挡| 欧美激情一区二区三区| 久久亚洲精品成人无码网站夜色| 18禁免费吃奶摸下激烈视频| 99国产精品久久久久久久日本竹 | 国产av无码精品色午夜| 人妻无码人妻有码中文字幕| 国产成人a人亚洲精品无码| 久久精品成人欧美大片| 野外做受又硬又粗又大视频√| 国产精品免费一区二区三区四区| 在线播放免费人成毛片试看|