在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca fascicularis Alpha-synuclein (SNCA)

In Stock
  • 中文名稱:
    獼猴SNCA重組蛋白
  • 貨號(hào):
    CSB-YP021912MOV
  • 規(guī)格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    SNCA; Alpha-synuclein
  • 種屬:
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • 蛋白長(zhǎng)度:
    Full Length
  • 來(lái)源:
    Yeast
  • 分子量:
    16.5kDa
  • 表達(dá)區(qū)域:
    1-140aa
  • 氨基酸序列
    MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFIKKDQLGKNEEGAPQEGILQDMPVDPDNEAYEMPSEEGYQDYEPEA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述:

    The DNA fragment encoding the 1-140aa of the Macaca fascicularis SNCA protein was fused with N-terminal 6xHis tag gene and then was inserted into the expression vector, which was subsequently transfected into the yeast cells for expression. The resulting product was further purified to obtain the recombinant Macaca fascicularis SNCA protein. The purity of this recombinant SNCA protein is greater than 90% assessed by Bandscan software analysis combined with SDS-PAGE. This recombinant SNCA protein showed a band on the gel with a molecular weight of approximately 17 kDa.

    In light of recent discoveries, researchers demonstrated that genetic triplication of the SNCA locus causes Parkinson disease. Another evidence discovered that the inhibition of SNCA enhances α‐synuclein in Parkinson's disease. SNCA is determined as one of susceptibility genes for Parkinson's disease. Albeit less is known about the mechanism of SNCA, SNCA is widely found to manipulate the mobility of synaptic vesicles. This regulation process is possible to disrupt the synaptic vesicle recycling and neurotransmitter release.

  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
  • 基因功能參考文獻(xiàn):
    1. Study shows that the age-dependent alpha-syn accumulation is correlated with an elevation of TRPC3 in the mitochondrial fractions isolated from monkey and mouse brains. In animal and cell models, alpha-syn overexpression was accompanied by an elevation of alpha-syn and TRPC3 in the mitochondrial fractions, and alpha-syn downregulation was associated with a reduction of the mitochondrial alpha-syn and TRPC3. PMID: 27904950
  • 亞細(xì)胞定位:
    Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted.
  • 蛋白家族:
    Synuclein family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 国产黑色丝袜在线视频| 精品国产不卡在线观看免费| 激情综合婷婷丁香五月情| 麻豆视传媒官网免费观看| 一本色道久久99一综合| а天堂中文官网| 高潮内射免费看片| 天天摸天天做天天爽天天弄| 在线观看无码av网址| 亚洲国产精品综合久久20| 日本高清在线一区二区三区| 女女同性av片在线观看免费| 秋霞最新高清无码鲁丝片| 一区二区三区毛aaaa片特级| 国产乱沈阳女人高潮乱叫老 | 蜜桃av久久久一区二区三区麻豆| 天堂va视频一区二区| 永久免费观看国产裸体美女| 成人天堂婷婷青青视频在线观看| 欧美私人情侣网站| 日夜啪啪一区二区三区| 国产亚洲欧美日韩在线观看一区| 粉嫩小泬无遮挡久久久久久| 丁香五月亚洲综合在线| 久久久久99精品成人片牛牛影视| 成人a大片在线观看| 国产深夜男女无套内射| 精品久久人人爽天天玩人人妻| 亚洲欧美日韩国产成人| 国产三级韩国三级日产三级| 久久精品日韩av无码| 最爽free性欧美人妖| 5x性社区免费视频播| 无码任你躁久久久久久老妇蜜桃| 一本一久本久a久久精品综合| 成人性生交大片免费看视频app| 亚洲va中文字幕无码久久| 国产亚洲精品一区在线播放| 柠檬福利第一导航在线| 99精品偷自拍| 久久成人国产精品免费|