Recombinant Lymphocytic choriomeningitis virus Nucleoprotein (N), partial

中文名稱：

Recombinant Lymphocytic choriomeningitis virus Nucleoprotein(N) ,partial
貨號：

CSB-YP362859LKW
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Lymphocytic choriomeningitis virus Nucleoprotein(N) ,partial
貨號：

CSB-EP362859LKW
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Lymphocytic choriomeningitis virus Nucleoprotein(N) ,partial
貨號：

CSB-EP362859LKW-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Lymphocytic choriomeningitis virus Nucleoprotein(N) ,partial
貨號：

CSB-BP362859LKW
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Lymphocytic choriomeningitis virus Nucleoprotein(N) ,partial
貨號：

CSB-MP362859LKW
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N
Uniprot No.：

P09992
別名：

N; Segment; S; Nucleoprotein; EC 3.1.13.-; Nucleocapsid protein; Protein N
種屬：

Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
基因功能參考文獻：
1. The viral nucleoprotein associates with double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha. PMID: 28539447
2. Immunofluorescence analysis demonstrated that T206 is required for the formation of the punctate replication and transcription complexes that are typically observed during lymphocytic choriomeningitis virus infection. PMID: 25922393
3. study demonstrates the role of the amino acid residue D471 in the self-association of lymphocytic choriomeningitis virus nucleoprotein; also document the dominant negative effect of D471G mutation on viral infection PMID: 23202457
4. Self-association of nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function. PMID: 22258244
5. The lymphocytic choriomeningitis virus nucleoprotein domain that interacted with Z overlapped with a previously documented C-terminal domain that counteracts the host type I interferon (IFN) response. PMID: 21976642
6. expression of the LCMV nucleoprotein (NP) is sufficient to inhibit both IFN production and nuclear translocation of IRF-3 PMID: 16940530
7. Absence of early nucleoprotein (NP)-specific cytotoxic T cells allows LCMV to replicate to higher levels resulting in severely impaired clearance in NP-tolerant mice. PMID: 18292534
8. Keratin 1, an intermediate filament network component, is the binding partner of the lymphocytic choriomeningitis virus nucleoprotein. PMID: 19494018
9. study mapped the regions and specific amino acid residues within nucleoprotein (NP) involved in its anti-IFN activity; identified a region spanning residues 382 to 386 as playing a critical role in the IFN-counteracting activity of NP PMID: 19710144
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亞細胞定位：

Virion. Host cytoplasm.
蛋白家族：

Arenaviridae nucleocapsid protein family
數據庫鏈接：

KEGG: vg:956592