在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Lassa virus Nucleoprotein (N)

In Stock
  • 中文名稱:
    Recombinant Lassa virus Nucleoprotein(N)
  • 貨號(hào):
    CSB-EP318401LNPe1
  • 規(guī)格:
    ¥3324
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP318401LNPe1 could indicate that this peptide derived from E.coli-expressed Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) N.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP318401LNPe1 could indicate that this peptide derived from E.coli-expressed Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) N.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    N; Nucleoprotein; EC 3.1.13.-; Nucleocapsid protein; Protein N
  • 種屬:
    Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
  • 蛋白長(zhǎng)度:
    Full Length
  • 來(lái)源:
    E.coli
  • 分子量:
    63.0 kDa
  • 表達(dá)區(qū)域:
    1-569aa
  • 氨基酸序列
    MSASKEIKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKSILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGMSGGNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSDLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDLESDGKPQKADSNNSSKSLQSAGFTAGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKRGGKEEITPHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFRTSTPRVVL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    Tag-Free
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
  • 基因功能參考文獻(xiàn):
    1. Importantly, authors demonstrate for the first time that Lassa virus nucleoprotein is involved in the inhibition of antigen-presenting cell-mediated NK cell responses. PMID: 25253342
    2. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection. PMID: 25253344
    3. NP trimerization is essential for transcription and/or replication of the viral genome. PMID: 23553456
    4. molecular dynamics (MD) simulations have been carried out to investigate the characters of deoxythymidine triphosphate binding to two forms of nucleoprotein. PMID: 22871039
    5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy PMID: 21917929
    6. Residues D389 and G392 of nucleoprotein were critical for Lassa virus viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress interferon in macrophages and dendritic cells. PMID: 21880754

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Virion. Host cytoplasm.
  • 蛋白家族:
    Arenaviridae nucleocapsid protein family
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: vg:956584



主站蜘蛛池模板: 国产欧美亚洲精品a| 中国china体内裑精亚洲日本| 亚洲中文字幕国产综合| 婷婷综合久久中文字幕| 欧美老熟妇乱子| 国产精品美女久久久久久久久| 97精品人妻一区二区三区香蕉 | 中文字幕亚洲乱码熟女在线| 亚洲人成电影网站色| 中文av伊人av无码av狼人| 国产精品久久久久蜜芽| 成年性生交大片免费看| 综合图区亚洲另类偷窥| 国产午夜亚洲精品理论片不卡| 国产微拍精品一区二区| 欧美日韩精品人妻狠狠躁免费视频| 亚洲国产精品久久亚洲精品| 麻豆蜜桃av蜜臀av色欲av| 少妇久久久久久人妻无码| 在线观看老湿视频福利| 男女吃奶做爰猛烈紧视频 | 三级特黄60分钟在线观看| 波多野结衣av无码久久一区| 国产午夜福利片| 成人美女黄网站色大色费全看| 久久人人做人人爽人人av| 免费无遮挡无码永久视频| yy111111少妇无码理论片| 噜噜噜av久久av苍井空| 亚洲精品久久久www小说| 99久久国产热无码精品免费| 日本道色综合久久影院| 人妻无码vs中文字幕久久av爆 | 久久久久久亚洲精品| 亚洲精品国产精品乱码视色| 亚洲系列一区中文字幕| 欧美亚洲熟妇一区二区三区| 久久人妻天天av| 无遮无挡三级动态图| 国语对白做受xxxxx在| av天堂亚洲区无码先锋影音|