在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Lassa virus Nucleoprotein (N)

In Stock
  • 中文名稱:
    Recombinant Lassa virus Nucleoprotein(N)
  • 貨號:
    CSB-EP318401LNP
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    N; Nucleoprotein; EC 3.1.13.-; Nucleocapsid protein; Protein N
  • 種屬:
    Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    79.0kDa
  • 表達區域:
    1-569aa
  • 氨基酸序列
    MSASKEIKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKSILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGMSGGNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSDLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDLESDGKPQKADSNNSSKSLQSAGFTAGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKRGGKEEITPHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFRTSTPRVVL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
  • 基因功能參考文獻:
    1. Importantly, authors demonstrate for the first time that Lassa virus nucleoprotein is involved in the inhibition of antigen-presenting cell-mediated NK cell responses. PMID: 25253342
    2. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection. PMID: 25253344
    3. NP trimerization is essential for transcription and/or replication of the viral genome. PMID: 23553456
    4. molecular dynamics (MD) simulations have been carried out to investigate the characters of deoxythymidine triphosphate binding to two forms of nucleoprotein. PMID: 22871039
    5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy PMID: 21917929
    6. Residues D389 and G392 of nucleoprotein were critical for Lassa virus viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress interferon in macrophages and dendritic cells. PMID: 21880754

    顯示更多

    收起更多

  • 亞細胞定位:
    Virion. Host cytoplasm.
  • 蛋白家族:
    Arenaviridae nucleocapsid protein family
  • 數據庫鏈接:

    KEGG: vg:956584



主站蜘蛛池模板: 亚洲国产成人爱av网站| 女人和拘做受全程看视频| 亚洲人成电影免费观看在线看| 最新在线精品国自产拍视频| 亚洲最大成人网站| 精品无码中文视频在线观看| 久久精品熟女亚州av麻豆| 亚洲色欲av无码成人专区| 欧美性大战久久久久xxx| 久久丫精品国产| 日韩无套内射视频6| 色综合久久中文字幕有码| 人妻精品久久久久中文字幕69| 少妇饥渴xxhd麻豆xxhd骆驼| 亚洲欧美日韩在线码| 麻豆国产成人av在线播放欲色| 又白又嫩毛又多15p| 丰腴饱满的极品熟妇| 亚洲欧美日韩中文加勒比| 久久天天躁狠狠躁夜夜2o2o| 狠狠人妻久久久久久综合蜜桃| 婷婷五月深深久久精品| 精品午夜国产福利观看| 婷婷网色偷偷亚洲男人甘肃| 亚洲日韩成人av无码网站| 中文在线а√在线天堂中文| 内射一区二区精品视频在线观看 | 拍真实国产伦偷精品| 国产精品午夜福利视频234区| 国产精品成人亚洲777| 国产成人午夜福利免费无码r| 中文字幕亚洲欧美日韩在线不卡 | 午夜天堂av天堂久久久| 国产激情综合五月久久| 久久国产午夜精品理论片| 中国熟妇人妻xxxxx| 中文字幕日韩精品一区二区三区| 日韩精品无码免费专区午夜不卡| 无码av免费一区二区三区a片| 免费1级做爰片在线观看爱| 亚洲精品久久久久久久久久久|