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  4. Recombinant Influenza A virus Polymerase acidic protein (PA), partial

Recombinant Influenza A virus Polymerase acidic protein (PA), partial

  • 中文名稱：
    Recombinant Influenza A virus Polymerase acidic protein(PA) ,partial
  • 貨號：
    CSB-YP356045IFZ
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Polymerase acidic protein(PA) ,partial
  • 貨號：
    CSB-EP356045IFZ
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Polymerase acidic protein(PA) ,partial
  • 貨號：
    CSB-EP356045IFZ-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Polymerase acidic protein(PA) ,partial
  • 貨號：
    CSB-BP356045IFZ
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Polymerase acidic protein(PA) ,partial
  • 貨號：
    CSB-MP356045IFZ
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PA
  • Uniprot No.：
  • 別名：
    PAPolymerase acidic protein; EC 3.1.-.-; RNA-directed RNA polymerase subunit P2
  • 種屬：
    Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
  • 基因功能參考文獻：
    1. The 22 amino acids of the N-terminal of PA are important for the shutoff activity. PMID: 29331676
    2. Computational analysis of the effect of polymerase acidic gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain has been presented. PMID: 29273880
    3. The human (H1N1) and avian (H7N9) strain PA-C-terminal domain proteins exhibit the same global topology as other strains in the absence of PB1, but differ extensively in the PB1 binding pocket. PMID: 25089892
    4. Naturally occurring mutations in the PA gene are key contributors to increased virulence. PMID: 24522908
    5. variants containing PA-A36T or PB2-H357N observed in the mouse-adapted descendants of 2009 pandemic H1N1 virus (pH1N1), A/Sichuan/1/2009 (SC), were characterized PMID: 22438920
    6. the C-terminal domain of PA (PAC) promoted interaction between PB1 and PB2 in the cytoplasm and that the N-terminal domain of PA inhibited the aberrant trimeric complex formation and assembly of higher-order oligomers induced by PAC in the cytoplasm. PMID: 22001919
    7. sequence of the 1918 influenza virus polymerase genes, PB1, PB2, and PA PMID: 16208372
    8. Adaptive mutations in PA cause enhanced polymerase activity and promote high virulence. PMID: 19403683

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  • 亞細胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Influenza viruses PA family
  • 數據庫鏈接：

    KEGG: vg:956535



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