在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human p53 apoptosis effector related to PMP-22 (PERP), partial

  • 中文名稱:
    人PERP重組蛋白
  • 貨號:
    CSB-YP839325HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PERP重組蛋白
  • 貨號:
    CSB-EP839325HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PERP重組蛋白
  • 貨號:
    CSB-EP839325HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PERP重組蛋白
  • 貨號:
    CSB-BP839325HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PERP重組蛋白
  • 貨號:
    CSB-MP839325HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PERP; KCP1; KRTCAP1; PIGPC1; THW; p53 apoptosis effector related to PMP-22; Keratinocyte-associated protein 1; KCP-1; P53-induced protein PIGPC1; Transmembrane protein THW
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
  • 基因功能參考文獻:
    1. Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy. PMID: 28323918
    2. Expression of p63-tGFP induces apoptosis with marked increase in PERP expression and associated p53 accumulation. Lack of p63 contributes to reduced PERP levels and impaired p53-mediated apoptosis in UM. PMID: 27584665
    3. Salmonella Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. PMID: 27078059
    4. The authors identified the tetraspanning membrane protein, p53 effector related to PMP-22 (PERP), as a Salmonella typhimurium SipA binding partner. PMID: 25486861
    5. Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity. PMID: 24066004
    6. Perp expression is reduced in human breast cancer cell lines PMID: 22515648
    7. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. PMID: 21451571
    8. Our comprehensive mutation scanning did not identify any Arrhythmogenic right ventricular cardiomyopathy (ARVC) causing mutations. PMID: 21254927
    9. Data suggest a temporal sequence whereby PERP loss occurs before E-cadherin loss in the progression of human SCC. PMID: 20975948
    10. findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by uveal melanoma tumours to modulate susceptibility to apoptosis PMID: 19040420
    11. pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation PMID: 19158843
    12. We demonstrate here that PERP induction is in fact compromised with some, but not all, Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate, AEC-patient derived TP63 mutants. PMID: 19353588
    13. A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. PMID: 10733530

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, desmosome. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM47 family
  • 組織特異性:
    Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
  • 數據庫鏈接:

    HGNC: 17637

    OMIM: 609301

    KEGG: hsa:64065

    STRING: 9606.ENSP00000397157

    UniGene: Hs.201446



主站蜘蛛池模板: 免费女人高潮流视频在线| 大伊香蕉在线精品视频75| 国产三级农村妇女在线 | 18禁止观看强奷免费国产大片| 在线永久无码不卡av| 男女啪啦猛视频免费| 国产精品一区二区 尿失禁| 欧美丰满熟妇xxxx性ppx人交| 久久久久久综合网天天| 青娱乐极品视觉盛宴av| 亚洲中文字幕乱码av波多ji| 色香阁综合无码国产在线| 国产亚洲精品a片久久久| 漂亮人妻被中出中文字幕| 毛片无码一区二区三区a片视频| 亚洲精品tv久久久久久久久久| 韩国午夜福利片在线观看 | 风韵丰满熟妇啪啪区老老熟女百度| 亚洲老熟女性亚洲| 中文字幕亚洲无线码在线一区| 成人精品一区二区三区中文字幕| 中文国产乱码在线人妻一区二区| 久久人午夜亚洲精品无码区| 天堂无码人妻精品一区二区三区| 亚洲日韩精品一区二区三区| 少妇放荡的呻吟干柴烈火动漫| 国产揄拍国产精品| 国产亚洲va在线电影| 永久免费看啪啪网址入口| 情侣作爱视频网站| 色综合久久88色综合天天| 狠狠狠色丁香综合婷婷久久| 亚洲欧美另类精品二区| 国产偷人爽久久久久久老妇app| 巨胸美乳无码人妻视频| 人妻护士在线波多野结衣| 国产明星xxxx色视频| 国产成人精品日本亚洲专区61| 男女免费观看做爰视频在线观看| 色综久久综合桃花网国产精品| 欧美乱强伦xxxx孕妇|