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PERP Recombinant Monoclonal Antibody

  • 中文名稱:
    PERP Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA616481A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of PERP expression in HeLa cells using PERP antibody. Green, isotype control; red, PERP.
    • Western blotting analysis using PERP antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PERP antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    PERP; P53 Apoptosis Effector Related To PMP22; KRTCAP1; PIGPC1; KCP1; THW; DJ496H19.1; P53 Apoptosis Effector Related To PMP-22; Keratinocyte-Associated Protein 1; PERP, TP53 Apoptosis Effector; P53-Induced Protein PIGPC1; Transmembrane Protein THW; KCP-1; Keratinocytes Associated Protein 1; Keratinocyte Associated Protein 1; 1110017A08Rik; EKVP7; OLMS2
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PERP protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    9C1
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
  • 基因功能參考文獻:
    1. Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy. PMID: 28323918
    2. Expression of p63-tGFP induces apoptosis with marked increase in PERP expression and associated p53 accumulation. Lack of p63 contributes to reduced PERP levels and impaired p53-mediated apoptosis in UM. PMID: 27584665
    3. Salmonella Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. PMID: 27078059
    4. The authors identified the tetraspanning membrane protein, p53 effector related to PMP-22 (PERP), as a Salmonella typhimurium SipA binding partner. PMID: 25486861
    5. Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity. PMID: 24066004
    6. Perp expression is reduced in human breast cancer cell lines PMID: 22515648
    7. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. PMID: 21451571
    8. Our comprehensive mutation scanning did not identify any Arrhythmogenic right ventricular cardiomyopathy (ARVC) causing mutations. PMID: 21254927
    9. Data suggest a temporal sequence whereby PERP loss occurs before E-cadherin loss in the progression of human SCC. PMID: 20975948
    10. findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by uveal melanoma tumours to modulate susceptibility to apoptosis PMID: 19040420
    11. pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation PMID: 19158843
    12. We demonstrate here that PERP induction is in fact compromised with some, but not all, Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate, AEC-patient derived TP63 mutants. PMID: 19353588
    13. A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. PMID: 10733530

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  • 亞細胞定位:
    Cell junction, desmosome. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM47 family
  • 組織特異性:
    Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
  • 數據庫鏈接:

    HGNC: 17637

    OMIM: 609301

    KEGG: hsa:64065

    STRING: 9606.ENSP00000397157

    UniGene: Hs.201446



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