在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat

  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat
  • 貨號(hào):
    CSB-YP518616HXD
  • 說明書:
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat
  • 貨號(hào):
    CSB-EP518616HXD
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat
  • 貨號(hào):
    CSB-EP518616HXD-B
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat
  • 貨號(hào):
    CSB-BP518616HXD
  • 說明書:
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype G Protein Tat
  • 貨號(hào):
    CSB-MP518616HXD
  • 說明書:
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    tat
  • Uniprot No.:
  • 別名:
    tat; Protein Tat; Transactivating regulatory protein
  • 種屬:
    Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-101
  • 氨基酸序列
    MDPVDPKLEP WNHPGSQPTT PCNKCYCKVC CWHCQVCFLN KGLGISYGRK KRRPRRGTPQ GSKDHQNPVP KQPLPITSGN PTGSEKPKKE VASKTETDPL D
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.; Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS. Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways. In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
  • 亞細(xì)胞定位:
    Host nucleus, host nucleolus. Host cytoplasm. Secreted.
  • 蛋白家族:
    Lentiviruses Tat family


主站蜘蛛池模板: 一本一本久久a久久综合精品| 国产精品乱码一区二区三| 18禁黄网站禁片免费观看国产| 99999久久久久久亚洲| 国产综合久久亚洲综合| 爽爽影院免费观看视频| 无码人妻品一区二区三区精99| 久久天天躁狠狠躁夜夜躁2012 | 国产亚洲精品影视在线| 少妇做爰免费视频了| 国产高清亚洲精品视bt天堂频| 双乳被一左一右吃着动态图| 人妻无码精品久久亚瑟影视| 最近中文字幕在线中文视频| 亚洲欧美日本国产专区一区 | 性久久久久久久| 亚洲情xo亚洲色xo无码| 日产欧美国产日韩精品| 国产伦精品一区二区三区免.费| 久久成人麻豆午夜电影| 男女车车的车车网站w98免费| 国产l精品国产亚洲区| 国产欧美va欧美va香蕉在线| 久久久无码精品亚洲日韩蜜桃| 最新版天堂资源中文官网| 天天影视性色香欲综合网| 亚洲国产精品第一区二区| 欧美国产日产一区二区| 久久99国产综合精品女同| 无码国模国产在线观看| 亚洲精品成a人在线观看| 小sao货水好多真紧h无码视频 | 无码国内精品久久人妻| 性欧美激情aa片在线播放| 国产欧美va天堂在线电影| 亚洲欧美日韩综合俺去了| 亚洲成a人片在线不卡一二三区| 国产a精彩视频精品视频下载| 久久午夜无码鲁丝片直播午夜精品| 色一情一乱一伦麻豆| 欧美一性一乱一交一视频|