在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef (nef)

  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef(nef)
  • 貨號:
    CSB-YP882533HGAJ
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef(nef)
  • 貨號:
    CSB-EP882533HGAJ
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef(nef)
  • 貨號:
    CSB-EP882533HGAJ-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef(nef)
  • 貨號:
    CSB-BP882533HGAJ
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Nef(nef)
  • 貨號:
    CSB-MP882533HGAJ
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    nef
  • Uniprot No.:
  • 別名:
    nef; Protein Nef; 3'ORF; Negative factor; F-protein) [Cleaved into: C-terminal core protein]
  • 種屬:
    Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-205
  • 氨基酸序列
    GGKWSKSSI VGWPAVGERM RQTPTAAEGV GAVSRDLDRR GAITSSNTRT TNPDLAWLEA QEEEEVGFPV RPQVPVRPMT YKAAVDLSHF LKEKGGLEGL IYSKKRGDTL DLWVYHTQGY FPDWQNYTPG PGIRYPLTLG WCFKLVPVDP EEVEKANEGE NNCLLHPMSQ HGMEDEDREV LRWKFDSSLA LRHIARERHP EFYQD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.; In infected CD4(+) T-lymphocytes, down-regulates the surface MHC-I, mature MHC-II, CD4, CD28, CCR5 and CXCR4 molecules. Mediates internalization and degradation of host CD4 through the interaction of with the cytoplasmic tail of CD4, the recruitment of AP-2 (clathrin adapter protein complex 2), internalization through clathrin coated pits, and subsequent transport to endosomes and lysosomes for degradation. Diverts host MHC-I molecules to the trans-Golgi network-associated endosomal compartments by an endocytic pathway to finally target them for degradation. MHC-I down-regulation may involve AP-1 (clathrin adapter protein complex 1) or possibly Src family kinase-ZAP70/Syk-PI3K cascade recruited by PACS2. In consequence infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Decreasing the number of immune receptors also prevents reinfection by more HIV particles (superinfection). Down-regulates host SERINC3 and SERINC5 thereby excluding these proteins from the viral particles. Virion infectivity is drastically higher when SERINC3 or SERINC5 are excluded from the viral envelope, because these host antiviral proteins impare the membrane fusion event necessary for subsequent virion penetration.; Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interaction with TCR-zeta chain up-regulates the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules on infected CD4(+) cells send attacking cytotoxic CD8+ T-lymphocytes into apoptosis.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 亞細胞定位:
    Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane.
  • 蛋白家族:
    Lentivirus primate group Nef protein family


主站蜘蛛池模板: 女人18毛片水最多| 美女扒开大腿让男人桶| 国产成人欧美综合在线影院| 亚洲日韩成人性av网站| 日韩成人无码v清免费| av在线 亚洲 天堂| 国产成人a亚洲精v品无码| 国产精品久久婷婷六月丁香| 亚洲精品一本之道高清乱码| 97在线观看播放| 日本一本二本三区免费| 免费无码a片一区二三区| 亚洲精品一区二区精华液| 免费裸体无遮挡黄网站免费看| 末发育娇小性色xxxxx视频| 欧美性色大片在线观看| 国产精品第一区揄拍无码| 亚洲日本va中文字幕久久| 免费国产a国产片高清| 国产午夜a理论毛片| 亚洲精品鲁一鲁一区二区三区| 国产精品99久久久精品无码| 国产精品老汉av| 中文字字幕在线精品乱码| 国产精欧美一区二区三区| 少妇特殊按摩高潮惨叫无码| 伦理片无码电影在线看| 亚洲日韩一区二区| 樱花草在线社区www| 日韩经典精品无码一区| 久久综合狠狠综合久久激情| 香蕉久久福利院| 久久亚洲中文字幕精品一区| 日韩精品无码不卡无码| 天堂а√在线最新版中文在线| 2021年国产精品专区丝袜| 色婷婷亚洲精品综合影院| 国模冰莲自慰肥美胞极品人体图| 久久精品中文无码资源站| 久久综合久久爱久久综合伊人 | 亚洲另类春色校园小说|