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  4. Recombinant Human herpesvirus 1 Major DNA-binding protein (DBP), partial

Recombinant Human herpesvirus 1 Major DNA-binding protein (DBP), partial

  • 中文名稱：
    Recombinant Human herpesvirus 1 Major DNA-binding protein(DBP) ,partial
  • 貨號：
    CSB-YP361243HWY
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Major DNA-binding protein(DBP) ,partial
  • 貨號：
    CSB-EP361243HWY
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Major DNA-binding protein(DBP) ,partial
  • 貨號：
    CSB-EP361243HWY-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Major DNA-binding protein(DBP) ,partial
  • 貨號：
    CSB-BP361243HWY
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Major DNA-binding protein(DBP) ,partial
  • 貨號：
    CSB-MP361243HWY
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DBP; ICP8; UL29Major DNA-binding protein
  • 種屬：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.
  • 基因功能參考文獻：
    1. The FNF (F1142, N1143, and F1144) and FW (F843 and W844) motifs are required for ICP8 self-interactions and these interactions may be important for the formation of prereplicative sites and replication compartments. PMID: 26676794
    2. The conserved D and E residues in ICP8 were required for binding metal cations and virus replication. PMID: 22491472
    3. DNA-binding activity of adeno-associated virus Rep 78 is required for complex formation with herpes simplex virus ICP8. PMID: 22205745
  • 亞細胞定位：
    Host nucleus.
  • 蛋白家族：
    Herpesviridae major DNA-binding protein family
  • 數據庫鏈接：

    KEGG: vg:2703458



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