在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human cGMP-gated cation channel alpha-1 (CNGA1), partial

  • 中文名稱:
    Recombinant Human cGMP-gated cation channel alpha-1(CNGA1),partial
  • 貨號:
    CSB-YP005642HU1
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human cGMP-gated cation channel alpha-1(CNGA1),partial
  • 貨號:
    CSB-EP005642HU1
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human cGMP-gated cation channel alpha-1(CNGA1),partial
  • 貨號:
    CSB-EP005642HU1-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human cGMP-gated cation channel alpha-1(CNGA1),partial
  • 貨號:
    CSB-BP005642HU1
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human cGMP-gated cation channel alpha-1(CNGA1),partial
  • 貨號:
    CSB-MP005642HU1
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
  • 基因功能參考文獻:
    1. Compound heterozygous mutations (NM000087, p.Y82X and p.L89fs) in exon 6 of CNGA1are pathogenic mutations in this Chinese family affected with autosomal recessive retinitis pigmentosa. Of which, p.Y82X is firstly reported in patient with autosomal recessive retinitis pigmentosa. PMID: 27391953
    2. The mut CNGA1 p.(G513R) protein was largely retained inside the cell rather than being targeted to the plasma membrane, suggesting the absence of cGMP-gated cation channels in the plasma membrane PMID: 26802146
    3. CNGA1 mutations are one of the most frequent autosomal recessive retinitis pigmentosa-causing mutations in the Japanese patients. PMID: 25268133
    4. Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR. PMID: 23032687
    5. Novel homozygous mutation R28X truncates CNGA1 very prematurely in patients with autosomal recessive retinitis pigmentosa. PMID: 12362048
    6. isolated an endogenous transcript (anti-CNG1) that is antisense to CNG1 mRNA; data suggest the suppression of CNG(alpha)1 expression by anti-CNG1 may play an important role in neuronal functions, especially in synaptic plasticity and cortical development PMID: 12388767
    7. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry PMID: 12432397
    8. The autosomal recessive retinitis pigmentosa in this family is caused by a mutation in CNGA1 gene. PMID: 15570217
    9. Expressed in a stage- and cell-specific manner in the rat testis. PMID: 15713832

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 49 (RP49)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
  • 組織特異性:
    Rod cells in the retina.
  • 數據庫鏈接:

    HGNC: 2148

    OMIM: 123825

    KEGG: hsa:1259

    STRING: 9606.ENSP00000384264

    UniGene: Hs.1323



主站蜘蛛池模板: 亚洲一区精品无码| 精品久久综合1区2区3区激情| 狠狠cao日日穞夜夜穞av| 九月婷婷人人澡人人添人人爽| 女人和拘做受全程看视频| 最新亚洲中文字幕在线观看| 99久久久无码国产精品9| 无码h片在线观看网站| 成人午夜亚洲精品无码区毛片| 亚洲精品综合欧美一区二区| 99国产精品久久久久久久成人热| 国产综合精品一区二区三区 | 香蕉免费一区二区三区在| 最近中文字幕免费大全在线| 精品国产午夜理论片不卡精品 | 国产福利一区二区麻豆| 国产精品久久久福利| 久久欧美国产伦子伦精品| 精品偷拍被偷拍在线观看| 无码人妻专区免费视频| 99久久99久久久精品齐齐| 亚洲成在人线av| 宅男宅女精品国产av天堂| 伊人久久综合无码成人网| 熟妇与小伙子matur老熟妇e| 首页 综合国产 亚洲 丝袜| 99精品国产在热久久无毒| 99热在线观看| 国产老妇伦国产熟女老妇视频| 冲田杏梨av一区二区三区| 欧美大香线蕉线伊人久久| 啦啦啦www在线观看免费视频 | 亚洲欧洲日产国码在线| 天天天天噜在线视频| 国产亚洲婷婷香蕉久久精品| 亚洲一线二线三线写真| 在线天堂资源www在线污| 人人妻人人澡人人爽精品日本| 国产成人小视频| 97久久婷婷五月综合色d啪蜜芽 | 正在播放重口老熟女露脸|