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  4. Recombinant Human Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1), partial

Recombinant Human Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1), partial

  • 中文名稱：
    人ZC3HAV1重組蛋白
  • 貨號：
    CSB-YP767190HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZC3HAV1重組蛋白
  • 貨號：
    CSB-EP767190HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZC3HAV1重組蛋白
  • 貨號：
    CSB-EP767190HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZC3HAV1重組蛋白
  • 貨號：
    CSB-BP767190HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZC3HAV1重組蛋白
  • 貨號：
    CSB-MP767190HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZC3HAV1
  • Uniprot No.：
  • 別名：
    ADP ribosyltransferase diphtheria toxin like 13; ARTD13; FLB6421; PARP13; ZAP; ZC3H2; ZC3HAV 1; Zc3hav1; ZC3HDC 2; ZC3HDC2; ZCCHV; ZCCHV_HUMAN; Zinc finger antiviral protein; Zinc finger CCCH domain containing protein 2; Zinc finger CCCH domain-containing antiviral protein 1; Zinc finger CCCH domain-containing protein 2; Zinc finger CCCH type antiviral 1; Zinc finger CCCH type antiviral protein 1; Zinc finger CCCH-type antiviral protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
  • 基因功能參考文獻：
    1. results indicate that low ZAP expression is common in hepatocellular carcinoma (HCC), is correlated with the progression of HCC and with a poorer prognosis for HCC patients, and plays an important role in HCC carcinogenesis PMID: 30196292
    2. In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci. PMID: 29158484
    3. The results indicate that an equilibrium between ZAP and enterovirus 3C protease controls viral infection. PMID: 29182509
    4. Herpes simplex virus 1 UL41 was shown for the first time to evade the antiviral function of human ZAP via its RNase activity. PMID: 26625984
    5. The association of the ZAP ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response. PMID: 26001115
    6. Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID: 26129669
    7. PARP13 regulates RNA in stress and disease. [review] PMID: 25851173
    8. PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. PMID: 25382312
    9. results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activity PMID: 25635049
    10. Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity. PMID: 24457973
    11. Data suggest that two isoforms of ZAP (ZAP-long and -short) inhibit replication of hepatitis B virus and replication of viral DNA in hepatocytes through posttranscriptional down-regulation of viral RNA. PMID: 23853601
    12. S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector. PMID: 23776219
    13. ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency PMID: 22951821
    14. The Thr851Ile SNP of ZC3HAV1 is significantly associated with susceptibility to multiple sclerosis PMID: 22319148
    15. Results indicate that ZAP inhibits HIV-1 by recruiting both the 5' and 3' mRNA degradation machinery to specifically promote the degradation of multiply spliced HIV-1 mRNAs. PMID: 21876179
    16. shorter isoform (ZAPS)stimulates interferon responses mediated by the RNA helicase RIG-I PMID: 21102435
    17. ZAP is a direct target gene of IRF3 action in cellular antiviral respon PMID: 20048147
    18. These findings suggest that ZAP recruits the cellular RNA degradation machinery for the degradation of viral RNA. PMID: 20451500
    19. Our findings demonstrate that ZAP can synergize with another IFN-induced factor(s) for maximal alphaviruses antiviral activity and that ZAP's intrinsic antiviral activity on virion production and cell survival can have cell-type-specific outcomes. PMID: 17928353
    20. This study finds that human ZAP encodes a potent antiviral activity against alphaviruses. PMID: 18225958
    21. ZAP, TIPARP and FLJ22693 proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID: 12851707

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  • 亞細胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23721

    OMIM: 607312

    KEGG: hsa:56829

    STRING: 9606.ENSP00000242351

    UniGene: Hs.133512



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