在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human YTH domain-containing family protein 1 (YTHDF1)

In Stock
  • 中文名稱:
    人YTHDF1重組蛋白
  • 貨號:
    CSB-EP874843HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    C20orf21; DACA 1; DACA-1; Dermatomyositis associated with cancer putative autoantigen 1; YTH domain family 1; YTH domain family member 1; YTH domain family protein 1; YTHD1; YTHD1_HUMAN; Ythdf1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    66.7 kDa
  • 表達區域:
    2-559aa
  • 氨基酸序列
    SATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYYPPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVESHPVLEKLKAAHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVRKERQSRNKQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

問答及客戶評論

 常見問題解答
Q:

是否使用考馬斯藍凝膠染色評估蛋白質純度? 能否提供完整的序列,包括標簽序列、目標蛋白序列和linker序列? 您能否提供有關優選緩沖液以最佳方式維持蛋白質活性的任何見解?

A:
這個目前是非活性蛋白,我們暫時未檢測過蛋白的活性,不保證100%具有活性哈; 純度我們是通過SDS-PAGE考馬斯亮藍染色檢測及使用Bandscan軟件分析來綜合評估的 保證純度是85%以上; 蛋白復溶建議收到后短暫離心,加無菌去離子水復溶即可,長期保存建議分裝后加10-50%甘油放于-20℃。

靶點詳情

  • 功能:
    Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules.
  • 基因功能參考文獻:
    1. YTHDF1 played an important role in regulating hepatocellular carcinoma cell cycle progression and metabolism PMID: 29439311
    2. The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription, while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover, silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells, while silencing the N(6)-methyladenosine erasers increased Gag expression. PMID: 27371828
    3. binding affinities of the YTH domains of three human proteins and yeast YTH domain protein Pho92 PMID: 26318451
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule.
  • 數據庫鏈接:

    HGNC: 15867

    OMIM: 616529

    KEGG: hsa:54915

    STRING: 9606.ENSP00000359364

    UniGene: Hs.744852



主站蜘蛛池模板: 制服视频在线一区二区| 激情无码人妻又粗又大| 无码丰满熟妇| 国精产品一区二区三区| 亚洲乱色伦图片区小说| 青青热久免费精品视频| 亚洲日韩欧洲乱码av夜夜摸 | 内射精品无码中文字幕| 色窝窝免费一区二区三区| 麻花豆传媒剧国产免费mv入口| 欧美牲交a欧美牲交aⅴ图片| 日本一卡2卡三卡4卡免费网站| 亚洲精品偷拍影视在线观看| 性欧美欧美巨大69| 日本丰满熟妇bbxbbxhd| 看国产一毛片在线看手机看| 亚洲愉拍二区一区三区| 揄拍成人国产精品视频| 怡春院国产精品视频| 国产亚洲另类无码专区| 日本高清色倩视频在线观看| 一区二区三区人妻无码| 人妻人人澡人人添人人爽人人玩| 日本高清www午色夜在线视频| 亚洲伊人情人综合网站| 亚洲欧美偷国产日韩| 骚动漫十八禁在线观看| 国产人久久人人人人爽| 四虎影视国产精品久久| 亚洲精品无码久久久久av老牛| 夜夜欢天天干| 亚洲人成电影在线播放| 国产午夜精华无码网站| 亚洲成av人片天堂网站| 人妻大战黑人白浆狂泄| 尤物国产在线精品福利三区| 中国老熟妇自拍hd发布| 一区二区视频| 国产麻豆 9l 精品三级站| 国精产品48x国精产品| 性无码专区一色吊丝中文字幕|