在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

YTHDF1 Antibody

  • 中文名稱:
    YTHDF1兔多克隆抗體
  • 貨號:
    CSB-PA002062
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using DACA-1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    C20orf21 antibody; DACA 1 antibody; DACA-1 antibody; Dermatomyositis associated with cancer putative autoantigen 1 antibody; YTH domain family 1 antibody; YTH domain family member 1 antibody; YTH domain family protein 1 antibody; YTHD1 antibody; YTHD1_HUMAN antibody; Ythdf1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human DACA-1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules.
  • 基因功能參考文獻:
    1. YTHDF1 played an important role in regulating hepatocellular carcinoma cell cycle progression and metabolism PMID: 29439311
    2. The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription, while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover, silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells, while silencing the N(6)-methyladenosine erasers increased Gag expression. PMID: 27371828
    3. binding affinities of the YTH domains of three human proteins and yeast YTH domain protein Pho92 PMID: 26318451
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule.
  • 數據庫鏈接:

    HGNC: 15867

    OMIM: 616529

    KEGG: hsa:54915

    STRING: 9606.ENSP00000359364

    UniGene: Hs.744852



主站蜘蛛池模板: 国产重口老太和小伙| 日本免费更新一二三区不卡| 天天摸夜夜摸夜夜狠狠添| 人与嘼av免费| 欧美肥胖老妇bbw| 亚洲国产成人久久综合碰| 久久69精品久久久久久hb| 国产成人青青久久大片| 国产乱子夫妻xx黑人xyx真爽| 日本特黄特黄刺激大片| 97国产超碰一区二区三区| 国产精品亚洲专区无码唯爱网| 超清av在线播放不卡无码| 亚洲精品国产字幕久久不卡| 另类亚洲小说图片综合区| 精品一区二区av天堂| 99久久国产露脸国语对白| 亚洲精品国产精品无码国模| 大ji巴好深好爽又大又粗视频| 成在线人av免费无码高潮喷水| 黄网站欧美内射| 另类国产精品一区二区| 久久99精品国产99久久6男男 | 熟妇人妻系列aⅴ无码专区友真希 内射囯产旡码丰满少妇 | 亚洲午夜精品久久久久久人妖| 强开小婷嫩苞又嫩又紧视频| 国产日韩精品欧美一区喷水| 国产福利自产拍| 真人作爱90分钟免费看视频| av片在线观看免费| 日韩综合亚洲色在线影院| 久久精品国产亚洲αv忘忧草| 抽插丰满内射高潮视频| 久久www免费人成_看片| 美女又大又黄www免费网站| 国产av一区二区三区最新精品 | 国产成人a区在线观看| 久久精品中文字幕第一页| 亚洲乱亚洲乱妇50p| 自拍偷在线精品自拍偷99| 亚洲成在人网站无码天堂|