在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Voltage-gated inwardly rectifying potassium channel KCNH2 (KCNH2), partial

  • 中文名稱:
  • 貨號:
    CSB-YP619634HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP619634HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP619634HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP619634HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP619634HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    KCNH2
  • Uniprot No.:
  • 別名:
    Voltage-gated inwardly rectifying potassium channel KCNH2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Potassium voltage-gated channel subfamily H member 2; Voltage-gated potassium channel subunit Kv11.1; KCNH2 ERG ERG1 HERG
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    569-611
  • 氨基酸序列
    YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKY
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).; Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.; Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
  • 基因功能參考文獻:
    1. Dominant-negative hERG1b G288S subunits suppress hERG1a currents. hERG1a G628S did not produce measurable currents and a mixture of hERG1a and hERG1a G628S markedly reduced hERG1a current PMID: 29089383
    2. novel variants in SCN5A, KCNH2 and KCNQ1 are associated with congenital long QT syndrome in a Polish population PMID: 30244407
    3. Data have defined the requirements for the susceptibility of LQT2 mutations to nonsense-mediated mRNA decay (NMD), and suggested that the majority of LQT2 nonsense and frameshift mutations are potential targets of NMD. Given that these specific mutations account for more than 30% of reported LQT2 mutations, the degradation of mutant mRNA by NMD is an important disease causing mechanism in the pathogenesis of LQT2. PMID: 29058182
    4. Applying the computational approaches in this study, have helped to elucidate the possible binding patterns and time evaluation dynamics of this drug at hERG1 channel models (both in its open and open-inactivated states) together with the crucial amino acid residues that mostly contribute in binding processes via interaction binding energy decomposition analysis. PMID: 28963955
    5. In a family afflicted by recurrent SIDS, post-mortem directed genetic testing was conducted. We demonstrate that despite the variant being present in both SIDS cases, KCNH2-p.Pro963Thr did not appreciably alter membrane surface expression of the hERG channel, or the biophysical properties, including deactivation gating. These findings suggest that KCNH2-p.Pro963Thr is not a monogenic disease-causing LQTS mutation PMID: 29331839
    6. It was also found that drug ionization may play a crucial role in preferential targeting to the open-inactivated state of the pore domain. pH-dependent hERG blockade by dofetilie was studied with patch-clamp recordings. The results show that low pH increases the extent and speed of drug-induced block. PMID: 27731415
    7. Fluconazole can prolong the QT interval and possess proarrhythmic activity due to its inhibition of hERG protein trafficking in experimental model. PMID: 27189953
    8. Our results underscore the importance of careful characterization of the impact of epitope fusion tags and of confirming complete sequence accuracy prior to genotype-phenotype studies for ion channel proteins such as hERG. PMID: 28544109
    9. Data show that ether-a-go-go-related 1 (hERG1) ion channel expression knockdown elicited a reversion of the epithelial to the mesenchymal state (EMT) profile in colorectal cancer HCT116 cells with a reacquisition of the epithelial-like profile. PMID: 28593575
    10. TBX20 can be considered a KCNH2-modifying gene. PMID: 28049825
    11. The KCNH2 intron 9 branch point is linked to the regulation of KCNH2 isoform expression in cardiomyocytes. PMID: 28433559
    12. Our findings suggest that the K897T polymorphism of KCNH2 may contribute to the occurrence of syncope in Andersen-Tawil syndrome. PMID: 28336205
    13. this study shows that hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance PMID: 27517748
    14. results reveal a novel mechanism by which stimulation of Kv11.1 channel leads to transcription of a potent tumor suppressor and suggest a potential therapeutic use for Kv11.1 channel activators PMID: 25945833
    15. QTi derived from Holter recordings predicts the mutation carrier state in families with Long QT syndromes. Increased 24-hour QT-RR slope is a diagnostic hint pointing in the direction of LQT2. PMID: 28212739
    16. The notorious ligand promiscuity of this channel earmarked hERG as one of the most important antitargets to be considered in early stages of drug development process. Herein we report on the development of an innovative and freely accessible web server for early identification of putative hERG blockers and non-blockers in chemical libraries. PMID: 27490970
    17. structural basis and role of the fast component of gating charge PMID: 29117522
    18. In HEK293 cells, CO inhibited wild-type, but not C723S mutant, Kv11.1 K(+) currents. Inhibition was prevented by an antioxidant, mitochondrial inhibitors, or inhibition of NO formation. PMID: 28743763
    19. data provide novel information about hypoxia-mediated hERG dysfunction and may have biological and clinical implications in hypoxia-associated diseases. PMID: 28784631
    20. Relative expression of Kv11.1 C-terminal isoforms can be regulated by modified U1 snRNA. PMID: 29066300
    21. Expression and functions of hERG are regulated by specific miRNAs. PMID: 27558843
    22. The present study shows clinical and genetic aspects of p.His492Tyr carriers and demonstrated two major findings; (1) KCNH2 p.His492Tyr variant presented symptomatic Romano-Ward syndrome in the presence of another LQTS-related gene mutation, in contrast, (2) heterozygous carriers had mild QT prolongation while additional triggers can be "latent" form of p.His492Tyr PMID: 27816319
    23. Homozygous carriers of CYP2B6*6 allele may be at increased risk for EFV-induced QT interval prolongation via inhibition of hERG. PMID: 27333947
    24. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits. PMID: 27916661
    25. atypical sequence of the pore helix of hERG may play a key role in determining how anionic lipids influence its gating PMID: 28314880
    26. Besides a prolonged cardiac repolarization phase, LQT2 patients display increased GLP-1, GIP, and insulin secretion and defective glucagon secretion, causing decreased plasma glucose and thus increased risk of hypoglycemia. PMID: 28235848
    27. BIMU8 is a potent blocker of hERG, NaV1.5 and CaV1.2 cardiac ion channels, inducing cardiac arrhythmias. PMID: 28552773
    28. The K897T polymorphism in the hERG1 gene has been reported as an important modifier of the IKr current, probably leading to QT interval prolongation-as it is observed in the LQT2 syndrome. PMID: 26109178
    29. Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker PMID: 28122216
    30. Study determined the structure of hERG using cryo-electron microscopy; the voltage sensors are depolarized, and the inner helical gate is open; an unusual geometry of the "central cavity" within hERG's ion conduction pathway; hERG contains a subtle difference in the structure of its selectivity filter compared to all other K+ channels so far analyzed. PMID: 28431243
    31. S1 region mutations would reduce both the action potential repolarizing current passed by Kv11.1 channels in cardiac myocytes, as well as the current passed in response to premature depolarizations that normally helps protect against the formation of ectopic beats. PMID: 28280240
    32. hERG mediated by proteases such as calpain may contribute to ischemia-associated QT prolongation and sudden cardiac death PMID: 27502273
    33. the two tyrosine residues in the Kv11.1 S4S5 linker play critical but distinct roles in the slow deactivation phenotype, which is a hallmark of Kv11.1 channels. PMID: 27317659
    34. Authors found that expression of HERG K(+) channels in MDS patients was significantly higher than controls and was lower than AML. PMID: 27077769
    35. M3-mAChR activation leads to enhancement of hsp expression via PKC-dependent phosphorylation of HSF1, thereby stabilizing the mutant hERG-FLAG protein. Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2. PMID: 27803431
    36. The solution structure of hERG cyclic nucleotide-binding homology domain. PMID: 27025590
    37. A novel heterozygous missense mutation in exon 7 of KCNH2 gene, causing a protein change p.F617V, was found in a family with life-threatening arrhythmias in women and clinical outcome typical for long QT2 syndrome. PMID: 25987402
    38. Activation of the alpha1-AR reduces the amplitude of IhERG and IKr through a positive shift in the activation half voltage, which reduces the channel availability at physiological membrane potentials. PMID: 27997898
    39. Monte Carlo method for predicting of cardiac toxicity of hERG blockers. PMID: 27067105
    40. A561VhERG exerts a potent dominantnegative effect on WThERG channels, resulting in decreased hERG currents and impairment of hERG membrane localization. PMID: 26847485
    41. Alternate mRNA transcripts encoding human ether-a-go-go-related gene (hERG) 1a and 1b subunits, which assemble to produce ion channels mediating cardiac repolarization, are physically associated during translation. This interaction occurred even when translation of 1b was prevented, indicating the transcripts associate independent of their encoded proteins. PMID: 27078096
    42. KCNH2 gene was initially discovered in the hippocampus, and its expression was later demonstrated in many regions of the central nervous system. In a study that included 343 LQTS probands, a personal history of seizures was more common in LQT2 than all other subtypes of LQTS combined. PMID: 25819988
    43. Result suggests that the mutation T613A in Kv 11.1 causes Long QT Syndrome type 2 due to a reduced repolarization reserve. PMID: 26173150
    44. The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of a delayed rectifier voltage gated K+ channel. PMID: 26519040
    45. In patients with genotype-positive Long QT syndrome, significant differences exist in the degree of daytime and nocturnal QTc prolongation. PMID: 26334569
    46. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1, 54 KCNH2 and 4 SCN5A mutations for long QT syndrome in China. PMID: 26496715
    47. we carried out an in silico screen for the naturally occurring hERG mutation, the M54T MiRP1 mutation, which has been implicated in drug-induced LQTS and arrhythmia. PMID: 26859003
    48. that activation of calpains by reactive oxygen species-dependent elevation of [Ca(2+)]i mediates Human ether-a-go-go-related gene protein degradation by IH PMID: 26659724
    49. The altered channel gating kinetics in combination with defective trafficking of mutated Kv11.1 channels is expected to result in reduced repolarizing current density and, thus, a long QT syndrome phenotype. PMID: 26403377
    50. Propose that berberine reduces hERG membrane stability with multiple mechanisms. PMID: 26543354

    顯示更多

    收起更多

  • 相關疾病:
    Long QT syndrome 2 (LQT2); Short QT syndrome 1 (SQT1)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.1/KCNH2 sub-subfamily
  • 組織特異性:
    Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
  • 數據庫鏈接:

    HGNC: 6251

    OMIM: 152427

    KEGG: hsa:3757

    STRING: 9606.ENSP00000262186

    UniGene: Hs.647099



主站蜘蛛池模板: 人妻少妇精品视频二区| 久久久国产精品亚洲一区| 高清粉嫩无套内谢国语播放| 免费国精产品自偷自偷免费看| 伊人激情av一区二区三区| 亚洲一区二区女搞男| 日本www一道久久久免费| 欧美乱人伦视频在线| 国产成人精品亚洲777人妖| 国产 | 久你欧洲野花视频欧洲1| 久久99成人免费| 欧美日韩国产一区二区三区不卡| 久久69精品久久久久久hb| 国产乱子伦60女人的皮视频| 一区二区视频| 国产精品igao视频网| 免费无码又爽又刺激软件下载| 国产制服丝袜欧美在线观看| 性一交一乱一伦一色一情孩交| 国产综合久久久久| 好男人日本社区www| 性按摩无码中文| 国模冰莲自慰肥美胞极品人体图| 美女高潮黄又色高清视频免费| 日韩av无码国产精品| 欧美xxxxx在线观看| 天堂а√8在线最新版在线| 999久久久国产精品消防器材| 日韩一区二区三区射精-百度| 亚洲国产日韩a在线播放| 中文字幕乱码亚洲无线三区| 国产喷水福利在线视频| 国产一卡2卡3卡四卡精品国色无边| 中国少妇内射xxxhd免费| 92久久精品一区二区| 春药玩弄少妇高潮吼叫| 中国猛少妇色xxxxx| 黑人巨茎大战白人美女| 国产日产欧洲无码视频| 国产亚洲日韩在线aaaa| 野外亲子乱子伦视频丶|