在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Voltage-dependent anion-selective channel protein 2 (VDAC2), partial

Recombinant Human Voltage-dependent anion-selective channel protein 2 (VDAC2), partial

  • 中文名稱：
    人VDAC2重組蛋白
  • 貨號：
    CSB-YP025824HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人VDAC2重組蛋白
  • 貨號：
    CSB-EP025824HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VDAC2重組蛋白
  • 貨號：
    CSB-EP025824HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VDAC2重組蛋白
  • 貨號：
    CSB-BP025824HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VDAC2重組蛋白
  • 貨號：
    CSB-MP025824HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    B-36 vdac; FLJ23841; hVDAC2; OTTHUMP00000019878; OTTHUMP00000019879; OTTHUMP00000019880; Outer mitochondrial membrane protein porin 2; POR; Porin-2; VDAC 2; VDAC-2; VDAC2; VDAC2_HUMAN; Vdac6; Voltage dependent anion channel 2; Voltage dependent anion selective channel protein 2; Voltage-dependent anion-selective channel protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.
  • 基因功能參考文獻：
    1. VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation. PMID: 27620692
    2. High methylation of the VDAC2 promoter CpGs in men with asthenospermia PMID: 27892527
    3. Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility. PMID: 27806320
    4. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. PMID: 26487717
    5. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. PMID: 26417093
    6. Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment. PMID: 25617717
    7. RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5. PMID: 25583988
    8. GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence PMID: 25187518
    9. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2. PMID: 24642864
    10. minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2. PMID: 23873934
    11. The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported. PMID: 22119777
    12. Binding of VDAC2 enhances eNOS activity in the pulmonary circulation. PMID: 22842492
    13. VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death PMID: 22114330
    14. distribution and function of VDAC2 in human spermatozoa PMID: 21347391
    15. VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions. PMID: 21241999
    16. The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia. PMID: 20809416
    17. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria PMID: 14739283
    18. VDAC-2 inhibits the Bak-mediated apoptotic response via Bax PMID: 15757910
    19. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane. Membrane.
  • 蛋白家族：
    Eukaryotic mitochondrial porin family
  • 組織特異性：
    Expressed in erythrocytes (at protein level). Expressed in all tissues examined.
  • 數據庫鏈接：

    HGNC: 12672

    OMIM: 193245

    KEGG: hsa:7417

    STRING: 9606.ENSP00000361635

    UniGene: Hs.355927



主站蜘蛛池模板： 亚洲综合久久一区二区| 精品欧美小视频在线观看| 最新在线精品国自产拍福利| 国产一区二区内射最近更新| 人人妻人人妻人人片av| 最新国产aⅴ精品无码| 欧美精品一产区二产区| 夜夜高潮夜夜爽国产伦精品| 国产亚洲美女精品久久久| 18禁真人抽搐一进一出在线| 粗大的内捧猛烈进出少妇视频| 亚洲精品伊人久久久大香| 第九色区av天堂| 99久久精品美女高潮喷水| 日韩爆乳一区二区无码| 国内精品久久人妻互换| 国产乱人偷精品人妻a片| 午夜理论在线观看不卡大地影院| 欧产日产国产精品| 亚洲中文字幕无码久久| 3d动漫精品啪啪一区二区下载| 国产av人人夜夜澡人人爽| 国产欧美日韩综合在线成| 免费的av网站手机版| 一本一道波多野结衣av一区| 69天堂人成无码免费视频| 丁香婷婷六月综合交清| 小鲜肉自慰网站| 无遮挡又爽又刺激的视频| 欧美国产伦久久久久久久| 国产无套露脸在线观看| 五月花成人网| 国产女人喷潮视频免费| 国产午夜av秒播在线观看| 波多野结衣中文字幕一区二区三区 | 动漫人妻h无码中文字幕| 国内乱码一线二线三线| 欧美老熟妇乱子伦视频| 国产yw8825免费观看网站| 亚洲欧美成αⅴ人在线观看| 亚洲色丰满少妇高潮18p|