在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VDAC2 Antibody

  • 中文名稱:
    VDAC2兔多克隆抗體
  • 貨號:
    CSB-PA025824LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA025824LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA025824LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VDAC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    B-36 vdac antibody; FLJ23841 antibody; hVDAC2 antibody; OTTHUMP00000019878 antibody; OTTHUMP00000019879 antibody; OTTHUMP00000019880 antibody; Outer mitochondrial membrane protein porin 2 antibody; POR antibody; Porin-2 antibody; VDAC 2 antibody; VDAC-2 antibody; VDAC2 antibody; VDAC2_HUMAN antibody; Vdac6 antibody; Voltage dependent anion channel 2 antibody; Voltage dependent anion selective channel protein 2 antibody; Voltage-dependent anion-selective channel protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Voltage-dependent anion-selective channel protein 2 protein (2-36AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,VDAC2 Antibody (CSB-PA025824LA01HU),的標記方式是Non-conjugated。對于VDAC2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA025824LB01HU VDAC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA025824LC01HU VDAC2 Antibody, FITC conjugated
    Biotin CSB-PA025824LD01HU VDAC2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.
  • 基因功能參考文獻:
    1. VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation. PMID: 27620692
    2. High methylation of the VDAC2 promoter CpGs in men with asthenospermia PMID: 27892527
    3. Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility. PMID: 27806320
    4. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. PMID: 26487717
    5. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. PMID: 26417093
    6. Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment. PMID: 25617717
    7. RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5. PMID: 25583988
    8. GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence PMID: 25187518
    9. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2. PMID: 24642864
    10. minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2. PMID: 23873934
    11. The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported. PMID: 22119777
    12. Binding of VDAC2 enhances eNOS activity in the pulmonary circulation. PMID: 22842492
    13. VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death PMID: 22114330
    14. distribution and function of VDAC2 in human spermatozoa PMID: 21347391
    15. VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions. PMID: 21241999
    16. The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia. PMID: 20809416
    17. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria PMID: 14739283
    18. VDAC-2 inhibits the Bak-mediated apoptotic response via Bax PMID: 15757910
    19. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane. Membrane.
  • 蛋白家族:
    Eukaryotic mitochondrial porin family
  • 組織特異性:
    Expressed in erythrocytes (at protein level). Expressed in all tissues examined.
  • 數據庫鏈接:

    HGNC: 12672

    OMIM: 193245

    KEGG: hsa:7417

    STRING: 9606.ENSP00000361635

    UniGene: Hs.355927



主站蜘蛛池模板: 国产成人无码av在线播放不卡| 国产乱子影视频上线免费观看| 无码人妻久久久一区二区三区| 国产真实夫妇交换视频| 亚洲中文久久精品无码照片| 男插女高潮一区二区| 国产精品系列无码专区| 国产成人av男人的天堂| 欧美黑人疯狂性受xxxxx喷水| 色综合久久久无码中文字幕| 国产高清女同学巨大乳在线观看| 亚洲精品久久久久一区二区三区 | 免费无码作爱视频| 国产99久久久欧美黑人刘玥| 亚洲午夜爱爱香蕉片| 青草视频在线播放| av无码av无码专区| 久久精品国产成人午夜福利| 国产香蕉尹人视频在线| 日本免费人成视频播放| 2020年国产精品| 亚洲国产欧美在线人成最新| 国产乱人激情h在线观看 | 精品日产高清卡4卡5区别| 精品成人av一区二区三区| 内射毛片内射国产夫妻| 非洲黑人性xxxx精品| 国产欧美日本亚洲精品一5区| 人妻丰满被色诱中文字幕| 亚洲欧美日韩综合在线一| 国产精品美女乱子伦高潮| 国产一区二区三区不卡av| 性大毛片视频| 女高中生第一次破苞av| 国产无遮挡18禁无码网站免费| 国产无套内射久久久国产| 熟女人妻aⅴ一区二区三区麻豆| 国产在线观看无码不卡| 东京热无码av男人的天堂| 国产第一页屁屁影院| 午夜香蕉成视频人网站|