在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VDAC2 Antibody

  • 中文名稱:
    VDAC2兔多克隆抗體
  • 貨號:
    CSB-PA025824LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA025824LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA025824LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VDAC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    B-36 vdac antibody; FLJ23841 antibody; hVDAC2 antibody; OTTHUMP00000019878 antibody; OTTHUMP00000019879 antibody; OTTHUMP00000019880 antibody; Outer mitochondrial membrane protein porin 2 antibody; POR antibody; Porin-2 antibody; VDAC 2 antibody; VDAC-2 antibody; VDAC2 antibody; VDAC2_HUMAN antibody; Vdac6 antibody; Voltage dependent anion channel 2 antibody; Voltage dependent anion selective channel protein 2 antibody; Voltage-dependent anion-selective channel protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Voltage-dependent anion-selective channel protein 2 protein (2-36AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,VDAC2 Antibody (CSB-PA025824LA01HU),的標記方式是Non-conjugated。對于VDAC2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA025824LB01HU VDAC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA025824LC01HU VDAC2 Antibody, FITC conjugated
    Biotin CSB-PA025824LD01HU VDAC2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.
  • 基因功能參考文獻:
    1. VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation. PMID: 27620692
    2. High methylation of the VDAC2 promoter CpGs in men with asthenospermia PMID: 27892527
    3. Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility. PMID: 27806320
    4. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. PMID: 26487717
    5. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. PMID: 26417093
    6. Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment. PMID: 25617717
    7. RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5. PMID: 25583988
    8. GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence PMID: 25187518
    9. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2. PMID: 24642864
    10. minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2. PMID: 23873934
    11. The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported. PMID: 22119777
    12. Binding of VDAC2 enhances eNOS activity in the pulmonary circulation. PMID: 22842492
    13. VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death PMID: 22114330
    14. distribution and function of VDAC2 in human spermatozoa PMID: 21347391
    15. VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions. PMID: 21241999
    16. The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia. PMID: 20809416
    17. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria PMID: 14739283
    18. VDAC-2 inhibits the Bak-mediated apoptotic response via Bax PMID: 15757910
    19. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane. Membrane.
  • 蛋白家族:
    Eukaryotic mitochondrial porin family
  • 組織特異性:
    Expressed in erythrocytes (at protein level). Expressed in all tissues examined.
  • 數據庫鏈接:

    HGNC: 12672

    OMIM: 193245

    KEGG: hsa:7417

    STRING: 9606.ENSP00000361635

    UniGene: Hs.355927



主站蜘蛛池模板: 国产jk白丝在线观看免费| 久久婷婷六月综合色液啪| 免费播放婬乱男女婬视频国产 | 中文无码熟妇人妻av在线| 挺进邻居丰满少妇的身体| 亚洲欧美国产制服图片区| 亚洲丰满熟女一区二区v| 久久久不卡国产精品一区二区| 真人做人60分钟啪啪免费看| 久久成人伊人欧洲精品| 亚洲中文字幕无码不卡电影| 欧美熟妇另类久久久久久多毛| 国产丝袜在线精品丝袜不卡| 99久久国产露脸精品竹菊传媒| а√在线中文网新版地址在线 | 国产精品igao视频网网址| 偷窥国产亚洲免费视频| 亚洲欧美日韩综合av| 两个人看的www视频免费完整版| 亚洲深深色噜噜狠狠爱网站 | 欧美牲交a欧美在线| 精品久久久久久777米琪桃花| 国产成人精品手机在线观看| 日韩一区二区a片免费观看| 伊人情人色综合网站| 国产成人18黄网站在线观看| 精品一二三区久久aaa片 | 久久精品久久精品久久39| 日本在线观看| 国产精品久久久久久无码五月| 无码精品国产d在线观看| 2021无码最新国产在线观看| 亚洲国产一区二区三区在观看| 成人黄网站高清免费视频| 大胆欧美熟妇xxbbwwbw高潮了| 性一交一乱一色一视频| 人人揉揉揉香蕉大免费| 国产成人a人亚洲精v品无码| 国产成人一区二区三区别| 成人av在线一区二区三区| 2019国产品在线视频|