在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Vacuolar protein sorting-associated protein 41 homolog (VPS41), partial

  • 中文名稱:
    人VPS41重組蛋白
  • 貨號:
    CSB-YP025911HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人VPS41重組蛋白
  • 貨號:
    CSB-EP025911HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人VPS41重組蛋白
  • 貨號:
    CSB-EP025911HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人VPS41重組蛋白
  • 貨號:
    CSB-BP025911HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人VPS41重組蛋白
  • 貨號:
    CSB-MP025911HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    VPS41
  • Uniprot No.:
  • 別名:
    VPS41; Vacuolar protein sorting-associated protein 41 homolog; S53
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    -
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex. May play a role in HOPS-independent function in the regulated secretory pathway.
  • 基因功能參考文獻:
    1. VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction PMID: 28931724
    2. VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. PMID: 25445562
    3. hVps41 and VAMP7 are specifically involved in the fusion of trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes. PMID: 23322049
    4. Vps41 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes. PMID: 23167963
    5. Both a functional heterotetrameric adaptor protein complex and a homotypic fusion and vacuole protein sorting-tethering complex are required for VPS41 to elicit neuroprotection in a transgenic model of Parkinson's disease. PMID: 22323726
    6. These data show that hVPS41 is protective against both alpha-syn and neurotoxic-mediated injury in invertebrate and cellular models of PD. PMID: 19850127

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane. Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle.;
  • 蛋白家族:
    VPS41 family
  • 數據庫鏈接:

    HGNC: 12713

    OMIM: 605485

    KEGG: hsa:27072

    STRING: 9606.ENSP00000309457

    UniGene: Hs.592184



主站蜘蛛池模板: 精品无码人妻一区二区三区品| 国产在线 | 欧洲| 97午夜理论片在线影院| 亚洲国产婷婷香蕉久久久久久| 亚洲色成人网站www永久蜜芽| 奇米在线7777在线精品| 日韩欧美精品有码在线| 自拍偷在线精品自拍偷免费| 国产亚洲精品字幕在线观看| 久久久久成人精品免费播放动漫 | 国语做受对白xxxxx在线| 欧美性受xxxx白人性爽| 免费观看一区二区三区| 亚洲 欧美 变态 另类 综合| 女子spa高潮呻吟抽搐| 免费无码国产v片在线观看| 久久人人做人人妻人人玩精品hd| 国产在不卡免费一区二区三| 伊人久久大香线焦av色| 激情爆乳一区二区三区| 亚洲天堂男人影院| 国色天香天天影院综合网| 被c到高潮疯狂喷水国产| 亚洲人成黄网站69影院| 精品国内在视频线2019| 国模无码一区二区三区| 亚洲αv无码一区二区三区四区| 国产又爽又黄又刺激的视频| 樱花草在线社区www中国| 午夜福利三级理论电影| 最近免费中文字幕中文高清百度| 麻豆自媒体 一区 二区| 麻豆精品偷拍人妻在线网址| 国产精品久久久久9999高清| 欧美xxxx做受欧美| 免费裸体黄网站18禁免费| 开心色婷婷色五月激情| 久久99精品久久久久久不卡| 亚洲国产精品成人久久 | 两个人日本www免费版| 日韩成人无码v清免费|