在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VPS41 Antibody

  • 中文名稱:
    VPS41兔多克隆抗體
  • 貨號:
    CSB-PA025911GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    VPS41
  • 別名:
    VPS41 antibody; Vacuolar protein sorting-associated protein 41 homolog antibody; S53 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human VPS41
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex. May play a role in HOPS-independent function in the regulated secretory pathway.
  • 基因功能參考文獻(xiàn):
    1. VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction PMID: 28931724
    2. VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. PMID: 25445562
    3. hVps41 and VAMP7 are specifically involved in the fusion of trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes. PMID: 23322049
    4. Vps41 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes. PMID: 23167963
    5. Both a functional heterotetrameric adaptor protein complex and a homotypic fusion and vacuole protein sorting-tethering complex are required for VPS41 to elicit neuroprotection in a transgenic model of Parkinson's disease. PMID: 22323726
    6. These data show that hVPS41 is protective against both alpha-syn and neurotoxic-mediated injury in invertebrate and cellular models of PD. PMID: 19850127

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endosome membrane. Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle.;
  • 蛋白家族:
    VPS41 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12713

    OMIM: 605485

    KEGG: hsa:27072

    STRING: 9606.ENSP00000309457

    UniGene: Hs.592184



主站蜘蛛池模板: 欧美成人精品高清视频在线观看| 超清精品丝袜国产自在线拍 | 西西人体做爰大胆性自慰| 无卡无码无免费毛片| 无码人妻啪啪一区二区| 99热成人精品热久久6网站 | 五月婷婷激情第四季| 欧美精品中文字幕在线视| 国产精品久久久久aaaa| 色悠久久久久久久综合网伊人| 国产成人亚洲精品无码电影| 国内高清a自拍视频| 亚洲精品中文字幕无码蜜桃| 性人久久网av| 国产aⅴ爽av久久久久久| 狠狠色噜噜狠狠狠777米奇888| 蜜桃视频一区二区三区在线观看| 国产精品国色综合久久| 热久久99这里有精品综合久久| 亚洲另类激情专区小说| 大又大粗又爽又黄少妇毛片| 鲁丝片一区二区三区毛片| 午夜内射中出视频| 中文无码日韩欧| 国模无码视频一区| 一边啪啪的一边呻吟声口述| 国产激情电影综合在线看| аⅴ资源中文在线天堂| 免费无码av片在线观看| 99久视频只有精品2019| 国产精品无码av一区二区三区 | 午夜时刻免费入口| 国产精品欧美成人片| 亚洲人成伊人成综合网久久久| 99久久无码私人网站| 久久精品无码免费不卡| 日本高清无卡码一区二区| 影音先锋无码aⅴ男人资源站| 亚洲不乱码卡一卡二卡4卡5卡 | 丰满人妻一区二区三区视频53| 亚洲日韩欧洲无码av夜夜摸|