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  4. Recombinant Human Vacuolar protein sorting-associated protein 16 homolog (VPS16), partial

Recombinant Human Vacuolar protein sorting-associated protein 16 homolog (VPS16), partial

  • 中文名稱：
    人VPS16重組蛋白
  • 貨號：
    CSB-YP863958HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人VPS16重組蛋白
  • 貨號：
    CSB-EP863958HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VPS16重組蛋白
  • 貨號：
    CSB-EP863958HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VPS16重組蛋白
  • 貨號：
    CSB-BP863958HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VPS16重組蛋白
  • 貨號：
    CSB-MP863958HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    VPS16
  • Uniprot No.：
  • 別名：
    HGNC:14584; hVPS16; mVPS16; RP11 12M19.2; Vacuolar protein sorting 16 (yeast); Vacuolar protein sorting 16 (Yeast); isoform CRA_a; Vacuolar protein sorting 16; Vacuolar protein sorting 16 homolog (S. cerevisiae); vacuolar protein sorting associated protein 16 homolog; Vacuolar protein sorting protein 16; Vacuolar protein sorting-associated protein 16 homolog; VPS16; VPS16_HUMAN; VPS16A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
  • 基因功能參考文獻：
    1. VPS16 is a new causative gene for adolescent-onset primary dystonia. PMID: 27174565
    2. HOPS subunit Vps16 recruits Vps33A to the human HOPS complex; residues 642-736 are necessary and sufficient for this interaction. PMID: 23901104
  • 相關疾病：
    VSP16 mutation have been found in one familly with adolescent-onset primary dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 亞細胞定位：
    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome.
  • 蛋白家族：
    VPS16 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 14584

    OMIM: 608550

    KEGG: hsa:64601

    STRING: 9606.ENSP00000369810

    UniGene: Hs.269577



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