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Recombinant Human Vacuolar protein sorting-associated protein 13C (VPS13C), partial

  • 中文名稱:
    人VPS13C重組蛋白
  • 貨號:
    CSB-YP761663HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人VPS13C重組蛋白
  • 貨號:
    CSB-EP761663HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人VPS13C重組蛋白
  • 貨號:
    CSB-EP761663HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人VPS13C重組蛋白
  • 貨號:
    CSB-BP761663HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人VPS13C重組蛋白
  • 貨號:
    CSB-MP761663HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    VPS13C; KIAA1421; Vacuolar protein sorting-associated protein 13C
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization.
  • 基因功能參考文獻:
    1. Our results suggest that rs329648 is associated with risk of developing PD in the Han Chinese population. Our findings should be verified in further studies, and they highlight the need for functional studies of MIR4697. PMID: 28380328
    2. The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved. PMID: 27329800
    3. This study found that rs2414739 (VPS13C) is associated with Parkinson disease in IRAN population. PMID: 27653855
    4. We describe truncating mutations in VPS13C associated with early-onset parkinsonism with rapid progression and widely distributed Lewy bodies. PMID: 26942284
    5. no detectable effect (with an OR >2.1) of the variants in GCKR, GIPR, ADCY5 and VPS13C on the response to sulfonylurea treatment, indicating that these variants are not significantly contributing to the risk of SH in patients with T2D PMID: 22956255
    6. The role of four loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children, was investigated. PMID: 21789219
    7. The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 A allele associates with glucose-stimulated insulin response in non-diabetic individuals from the general population, suggesting an impaired beta cell function as an intermediary diabetes-related trait. PMID: 21249489

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  • 相關疾病:
    Parkinson disease 23, autosomal recessive, early onset (PARK23)
  • 亞細胞定位:
    Mitochondrion outer membrane.
  • 蛋白家族:
    VPS13 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 23594

    OMIM: 608879

    KEGG: hsa:54832

    STRING: 9606.ENSP00000261517

    UniGene: Hs.511668



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