在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Vacuolar protein sorting-associated protein 13A (VPS13A), partial

Recombinant Human Vacuolar protein sorting-associated protein 13A (VPS13A), partial

  • 中文名稱：
    人VPS13A重組蛋白
  • 貨號：
    CSB-EP850425HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    VPS13A
  • Uniprot No.：
  • 別名：
    VPS13A; CHAC; KIAA0986; Vacuolar protein sorting-associated protein 13A; Chorea-acanthocytosis protein; Chorein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    28.5kDa
  • 表達(dá)區(qū)域：
    3037-3140aa
  • 氨基酸序列
    RPPRFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation.
  • 基因功能參考文獻(xiàn)：
    1. Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls. PMID: 28244758
    2. These results suggest that PI3P regulates the functioning of Vps13, both in protein trafficking and actin cytoskeleton organization. Attenuation of PI3P-binding ability in the mutant hVps13A protein may be one of the reasons for its mislocalization and disrupted function in cells of patients suffering from chorea-acanthocytosis . PMID: 28334785
    3. Chorein is a stimulator of Orai1 expression and thus of store operated Ca2+ entry. PMID: 27960157
    4. Patients with chorea-acanthocytosis carrying a VPS13A mutation present with focal, treatment-resistant seizures. PMID: 26813249
    5. Defective chorein is accompanied by significant structural disorganization of all cytoskeletal structures. PMID: 26316086
    6. VPS13A-depleted cells showed accumulation of autophagic markers and impaired autophagic flux PMID: 25996471
    7. Chorein is expressed in various cancer cells. In cells with high chorein expression levels chorein silencing promotes apoptotic cell death, an effect paralleled by down-regulation of PI-3K activity and BCL-2/Bax expression ratio. PMID: 25871399
    8. Discovery of new mutations may clarify the pathogenic roles of chorein in chorea-acanthocytosis as well as in the retina PMID: 23746940
    9. chorein interacts with beta-adducin and beta-actin. PMID: 24129186
    10. Data indicate functions of chorein, i.e., regulation of secretion and aggregation of blood platelets. PMID: 23568775
    11. This study demonistrated that neuroacanthocytosis disorders has heterozygotes for mutations in the VPS13A gene. PMID: 22038564
    12. Results reveal chorein as a novel powerful regulator of cytoskeletal architecture and cell survival, thus explaining erythrocyte misshape and possibly neurodegeneration in chorea-acanthocytosis. PMID: 22227296
    13. these results suggest that chorein is involved in exocytosis of dense-core vesicles. PMID: 22366033
    14. Frameshift mutations of VPS genes and losses of expression of Vps13A and Vps35 proteins are common in gastric cancers and colorectal cancers with high microsatellite instability. PMID: 21733561
    15. identified 36 pathogenic mutations of VPS13A, 20 of which were previously unreported, including two novel copy number variations PMID: 21598378
    16. A mutation was identified in the VPS13A gene, responsible for autosomal recessive chorea-acanthocytosis. PMID: 21987550
    17. Founder mutation and single-nucleotid epolymorphisms in chorea-acanthocytosis in French-Canadians. PMID: 15918062
    18. The index patient was homozygous for a 3889C>T nonsense mutation in the VPS13A gene and presented with a typical ChAc phenotype. PMID: 17673232
    19. A Mexican family, two sister, after mutation screening of the VPS13A gene revealed homozygosity for the frameshift mutation c.3556_3557dupAC in exon 33. PMID: 17998451

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Choreoacanthocytosis (CHAC)
  • 亞細(xì)胞定位：
    Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Lipid droplet. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
  • 蛋白家族：
    VPS13 family
  • 組織特異性：
    Widely expressed. Higher expression is found in brain, heart, skeletal muscle and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1908

    OMIM: 200150

    KEGG: hsa:23230

    STRING: 9606.ENSP00000353422

    UniGene: Hs.459790



主站蜘蛛池模板： 丰满少妇人妻久久久久久| 无套内射在线观看theporn| 激情人妻另类人妻伦| 日日狠狠久久8888偷偷色| 国产综合有码无码视频在线 | 久久天天躁狠狠躁夜夜爽| 国内精品视频一区二区三区| 久久国产36精品色熟妇| 国产色欲色欱www在线| 国产成人午夜无码电影在线观看| 香蕉久久精品日日躁夜夜躁夏| 女人喷液抽搐高潮视频| 亚洲影院天堂中文av色| 亚洲精品久久国产精品| 久久亚洲精品无码va白人极品 | 97影院在线午夜| 亚洲日本中文字幕乱码在线| 亚洲欧洲日产国无高清码图片 | 18无码粉嫩小泬无套在线观看| 色噜噜狠狠色综合久夜色撩人| 色哟哟在线视频精品一区| 国产熟妇人妻精品一区二区动漫| 无码里番纯肉h在线网站| 国产成人精品午夜福利| 日本熟妇浓密毛毛多| 欧美日产国产精品日产| 国产白嫩美女在线观看| 久久精品人妻一区二区三区 | 人与狗精品aa毛片| 人妻丰满av无码中文字幕| 国产精品区免费视频| 无码色偷偷亚洲国内自拍| 台湾无码av一区二区三区| 欧洲av无码放荡人妇网站| 日韩中文字幕在线一区二区三区| 精品少妇人妻av久久久| 亚洲色大成影网站www永久| 亚洲 欧美 国产 日韩 中文字幕| 久久超碰精品一夜七次郎 | 99er热精品视频| 日本护士╳╳╳hd少妇|