在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Urea transporter 1 (SLC14A1)-VLPs

  • 中文名稱:
    Recombinant Human Urea transporter 1 (SLC14A1)-VLPs
  • 貨號:
    CSB-MP615678HU(A4)-C
  • 規格:
    ¥5250
  • 圖片:
    • CSB-MP615678HU(A4)-C is detected by Mouse anti-6*His monoclonal antibody.
  • 其他:

產品詳情

  • 純度:
    The purity information is not available for VLPs proteins.
  • 生物活性:
    Not Test
  • 基因名:
    SLC14A1
  • Uniprot No.:
  • 別名:
    Solute carrier family 14 member 1;Urea transporter, erythrocyte
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    43.9 kDa
  • 表達區域:
    1-389aa
  • 氨基酸序列
    MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human Chinese?hamster?ovary?cells?(CHO).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended. ·The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
  • 基因功能參考文獻:
    1. The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased. PMID: 29279852
    2. In addition to the well known Polynesian Jknull allele, three Jknull alleles were detected including one novel Jknull allele: JKA (130A, 220G). PMID: 26969102
    3. The Jk(a-b-) phenotype in the Chinese population shows several different molecular mechanisms. A novel missense mutation nt737T>G of JK gene was found as associated with Jk(a-b-) phenotype. PMID: 25807964
    4. Data indicate that urea transporter UT-A1 successfully trafficking to the apical membrane of the epithelial cells is crucial for the regulation of urea transport. PMID: 23698785
    5. Results suggested that polymorphism in TERTC/T and SLC14A1C/T confirmed high risk for BC in North Indian population. PMID: 25218484
    6. Reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder urothelial carcinoma. PMID: 25445116
    7. Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes. PMID: 25298342
    8. Studies indicate that acid substitution in the urea transporter Slc14A1 UT-B protein determines the erythrocyte Kidd blood group antigen. PMID: 25298346
    9. UT-B should be considered as a new member of the water channel family. PMID: 24376529
    10. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. PMID: 24845979
    11. these data confirm the presence of UT-B protein within the human bladder. PMID: 25209859
    12. Novel polymorphisms in exon 9 of the JSLC14A1 gene in Japanese individuals associated with the Jk(a-b-) phenotype. PMID: 24877238
    13. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity. PMID: 23486518
    14. SLC14A1 could be a unique urea transporter in the bladder that has the ability to influence urine concentration and that this mechanism might explain the increased bladder cancer susceptibility associated with rs10775480. PMID: 23754249
    15. Inhibitor and mutagenesis studies and results of molecular dynamics simulations suggest that NH and HO pass through the three monomeric urea channels in UT-B. PMID: 23552862
    16. Four novel JK-null alleles were noted to be associated with the Jk(a-b-) phenotype. PMID: 22738189
    17. the rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier PMID: 22733730
    18. Loss of SLC14A1 is associated with lung adenocarcinoma. PMID: 22223368
    19. rs17674580, or other sequence variants of SLC14A1, indirectly modifies urinary bladder cancer risk by affecting urine production. PMID: 21750109
    20. Genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis. PMID: 21824976
    21. A new allele JK*01W has 3 changes (130G>A, 588A>G, Intron 9-46a>g)in addition to 838G. It is associated with weak expression of the Jk-a antigen on erythrocytes. PMID: 21309779
    22. Results illustrate differential protein abundance of functional UT-B protein in different sections of the human colon, strongly correlating to regions that contain the largest populations of intestinal bacteria. PMID: 19926813
    23. gene encodes the Kidd blood group antigens PMID: 12093813
    24. Kidd antigen/UT-B urea transporter is physiologically expressed in the human colon epithelium, where it could participate in the transport of urea across the colon mucosa. PMID: 14985236
    25. high frequency of JK null allele in Taiwanese indigenous groups PMID: 18713105
    26. Three blood group antigens genes, namely CD55, CD151, and SLC14A1, have been subjected to balancing selection, a process, rare outside MHC genes, which maintains variability at a locus. PMID: 18997004

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Urea transporter family
  • 組織特異性:
    Detected in erythrocytes (at protein level). Erythrocytes.
  • 數據庫鏈接:

    HGNC: 10918

    OMIM: 111000

    KEGG: hsa:6563

    STRING: 9606.ENSP00000390637

    UniGene: Hs.101307



主站蜘蛛池模板: 狂野av人人澡人人添| av天堂午夜精品一区| 国产精品99久久久久久宅男| 久久精品aⅴ无码中文字字幕重口| 日本最新免费二区| 亚洲熟少妇在线播放999| 久久精品免费一区二区三区| 一二区成人影院电影网| 亚洲最大av无码国产| 日产精品高潮呻吟av久久| 国产在线清纯极品美女援交| 国产精品久久久久久久久久免费| 色综合久久久久久久久久| 精产国品一区二区三产区| 男人扒开女人双腿猛进免费视频| 无码超乳爆乳中文字幕| 熟女人妻在线视频| 久久久水蜜桃国产成人网站| 青青草免费国产线观720| 精品亚洲麻豆1区2区3区| 欧美乱码精品一区二区三区| 免费现黄频在线观看国产| 亚洲国产精品ⅴa在线播放| 色综合久久无码五十路人妻| 亚洲人成精品久久久久桥| 午夜视频在线在免费| 成 人影片 aⅴ毛片免费观看| 午夜精品一区二区三区免费视频| 欧美孕妇乳喷奶水在线观看| 精品国产亚洲午夜精品av| 国外亚洲成av人片在线观看| 日本大片免a费观看视频三区| 国产99久久亚洲综合精品西瓜tv| 亚洲一二区制服无码中字 | 欧美高清性色生活片免费观看 | 无码人妻aⅴ一区二区三区 | 亚洲综合色区另类小说| 亚洲欧洲成人a∨在线| 国产精品熟女高潮视频| 日韩精品无码中文字幕一区二区| 亚洲国产日韩制服在线观看|