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  4. Recombinant Human Ubiquitin carboxyl-terminal hydrolase 25 (USP25), partial

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 25 (USP25), partial

  • 中文名稱：
    人USP25重組蛋白
  • 貨號：
    CSB-YP883400HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人USP25重組蛋白
  • 貨號：
    CSB-EP883400HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人USP25重組蛋白
  • 貨號：
    CSB-EP883400HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人USP25重組蛋白
  • 貨號：
    CSB-BP883400HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人USP25重組蛋白
  • 貨號：
    CSB-MP883400HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Deubiquitinating enzyme 25; Ubiquitin carboxyl-terminal hydrolase 25; Ubiquitin specific peptidase 25; ubiquitin specific protease 25; ubiquitin specific protease USP25; Ubiquitin thiolesterase 25; Ubiquitin-specific-processing protease 25; UBP25_HUMAN; USP on chromosome 21; USP21; USP25
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
  • 基因功能參考文獻：
    1. Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation. PMID: 29518389
    2. USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization and demonstrated that USP25 deficiency could promote the degradation of tankyrases and consequent stabilization of Axin to antagonize Wnt signaling PMID: 28619731
    3. Results suggest inhibition of Usp25's catalytic activity upon the non-covalent binding of SUMO2 to the Usp25 SUMO-interacting motif, and found that SUMO2 can competitively block the interaction between the Usp25 ubiquitin-binding region and its ubiquitin substrates. PMID: 28538147
    4. We detected SNPs at USP25 with associations of genome-wide significance for Inflammatory Bowel Disease. PMID: 27693347
    5. REM Sleep Behavior Disorder patients with homozygous USP25 rs2823357 progressed to synucleinopathies faster than others. PMID: 25929833
    6. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination. PMID: 25755282
    7. These findings indicate that miR-200c exerts tumor-suppressive effects for NSCLC through the suppression of USP25 expression and suggests a new therapeutic application of miR-200c in the treatment of NSCLC. PMID: 24997798
    8. USP25 is a novel deubiquitinating enzyme negatively regulating virus-induced interferon-beta production. PMID: 24260525
    9. a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome. PMID: 22590560
    10. Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation. PMID: 21480003
    11. the second SH2 domain of SYK physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation PMID: 19909739
    12. characterization of alternatively spliced products and tissue-specific isoforms PMID: 11597335
    13. downregulation of USP25 gene in human lung cancer PMID: 18523997
    14. Seven amino acids in the SIM of USP25 are sufficient for SUMO2/3-specific binding and conjugation PMID: 18538659
    15. Data show that USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains. PMID: 19440361

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  • 亞細胞定位：
    Cytoplasm.; [Isoform USP25m]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and
  • 數據庫鏈接：

    HGNC: 12624

    OMIM: 604736

    KEGG: hsa:29761

    STRING: 9606.ENSP00000285679

    UniGene: Hs.743994



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