在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP25 Antibody

  • 中文名稱:
    USP25兔多克隆抗體
  • 貨號:
    CSB-PA025715GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Deubiquitinating enzyme 25 antibody; Ubiquitin carboxyl-terminal hydrolase 25 antibody; Ubiquitin specific peptidase 25 antibody; ubiquitin specific protease 25 antibody; ubiquitin specific protease USP25 antibody; Ubiquitin thiolesterase 25 antibody; Ubiquitin-specific-processing protease 25 antibody; UBP25_HUMAN antibody; USP on chromosome 21 antibody; USP21 antibody; USP25 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human USP25
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
  • 基因功能參考文獻:
    1. Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation. PMID: 29518389
    2. USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization and demonstrated that USP25 deficiency could promote the degradation of tankyrases and consequent stabilization of Axin to antagonize Wnt signaling PMID: 28619731
    3. Results suggest inhibition of Usp25's catalytic activity upon the non-covalent binding of SUMO2 to the Usp25 SUMO-interacting motif, and found that SUMO2 can competitively block the interaction between the Usp25 ubiquitin-binding region and its ubiquitin substrates. PMID: 28538147
    4. We detected SNPs at USP25 with associations of genome-wide significance for Inflammatory Bowel Disease. PMID: 27693347
    5. REM Sleep Behavior Disorder patients with homozygous USP25 rs2823357 progressed to synucleinopathies faster than others. PMID: 25929833
    6. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination. PMID: 25755282
    7. These findings indicate that miR-200c exerts tumor-suppressive effects for NSCLC through the suppression of USP25 expression and suggests a new therapeutic application of miR-200c in the treatment of NSCLC. PMID: 24997798
    8. USP25 is a novel deubiquitinating enzyme negatively regulating virus-induced interferon-beta production. PMID: 24260525
    9. a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome. PMID: 22590560
    10. Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation. PMID: 21480003
    11. the second SH2 domain of SYK physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation PMID: 19909739
    12. characterization of alternatively spliced products and tissue-specific isoforms PMID: 11597335
    13. downregulation of USP25 gene in human lung cancer PMID: 18523997
    14. Seven amino acids in the SIM of USP25 are sufficient for SUMO2/3-specific binding and conjugation PMID: 18538659
    15. Data show that USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains. PMID: 19440361

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.; [Isoform USP25m]: Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase C19 family
  • 組織特異性:
    Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and
  • 數據庫鏈接:

    HGNC: 12624

    OMIM: 604736

    KEGG: hsa:29761

    STRING: 9606.ENSP00000285679

    UniGene: Hs.743994



主站蜘蛛池模板: 欧美阿v高清资源在线| 色九月亚洲综合网| 国语自产精品视频在 视频| 97色精品视频在线观看| 亚洲欧美成人一区二区三区| 无码人妻精品一区二区三| 精品午夜福利在线视在亚洲 | 久久精品中文字幕有码| 国产三级在线观看完整版| 国产午夜成人av在线播放| 亚洲人成电影网站色迅雷| 亚洲精品久久久久中文字幕m男| 国产无遮挡吃胸膜奶免费看| 女人被狂躁60分钟视频| 国产巨大爆乳在线观看| 人妻中文乱码在线网站| 亚洲a∨国产av综合av下载 | 亚洲精品成人福利网站app| 日本亚洲色大成网站www久久| 人妻另类 专区 欧美 制服 | 免费观看黄网站在线播放| 国产成人av一区二区三区在线| 亚洲 欧美 另类 综合 日韩| 色欲综合久久躁天天躁| 狼人无码精华av午夜精品| 日韩国产高清一区二区| 女人夜夜春高潮爽a∨片| 国产综合内射日韩久| 中文字幕精品久久久乱码乱码| 免费看国产精品3a黄的视频| 国产精品亚洲欧美中字| 麻豆亚洲一区| 日本精品αv中文字幕| 潮喷无码正在播放| 亚洲午夜久久久影院伊人| 中文无码精品a∨在线观看不卡| av网站的免费观看| 色噜噜狠狠狠狠色综合久| 精品视频一区二区三区在线观看| 黄网站免费永久在线观看下载| 日本中文字幕乱码免费|