在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 21 (USP21), partial

In Stock
  • 中文名稱:
    人USP21重組蛋白
  • 貨號:
    CSB-EP891945HU1
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Deubiquitinating enzyme 21;Ubiquitin thioesterase 21;Ubiquitin-specific-processing protease 21
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    48.3 kDa
  • 表達區(qū)域:
    200-565aa
  • 氨基酸序列
    MAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
  • 基因功能參考文獻:
    1. Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus. PMID: 27174732
    2. Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences. PMID: 27436899
    3. USP21 binds to the promoter region of IL-8 and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma PMID: 27259257
    4. USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficient RAD51 loading at DNA double-strand breaks. PMID: 28743957
    5. a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses. PMID: 28254948
    6. USP21 recruits and stabilises Gli1 at the centrosome. PMID: 27621083
    7. USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG PMID: 27956178
    8. The protein stability of IL-33 is maintained by USP21 through deubiquitination PMID: 25197364
    9. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 PMID: 23395819
    10. Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos. PMID: 22298430
    11. Study report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15, but is inactive against NEDD8. PMID: 21399617
    12. USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1. PMID: 19910467

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase C19 family, USP21 subfamily
  • 組織特異性:
    Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
  • 數據庫鏈接:

    HGNC: 12620

    OMIM: 604729

    KEGG: hsa:27005

    STRING: 9606.ENSP00000289865

    UniGene: Hs.8015



主站蜘蛛池模板: 色琪琪丁香婷婷综合久久| 四虎影视精品永久在线观看| 看成年全黄大色黄大片| 国产午夜鲁丝片av无码免费| 国产日韩在线视看第一页 | 欧美乱大交xxxxx潮喷l头像| 国产精品成人久久电影| 亚洲精品久久7777777国产| 久久不见久久见免费视频观看 | 无码精品人妻一区二区三区免费看| 麻豆国产精品va在线观看| 欧美日韩一本无线码专区| 精品免费国产一区二区三区四区介绍| 国产乱子夫妻xx黑人xyx真爽| 男女野外做爰全过程69影院| 国产精品夜夜春夜夜爽久久| av人摸人人人澡人人超碰下载| 日韩精品成人无码专区免费| 日韩理论午夜无码| 国色天香成人一区二区| 又白又嫩毛又多15p| 亚洲日韩v无码中文字幕| 日本熟妇色一本在线观看| 欧美丰满熟妇xxxx性ppx人| 丰满熟女人妻中文字幕免费| 国产suv精品一区二区6| 久久国产精品免费一区| 国产精品亚洲专区无码破解版| 俄罗斯丰满熟妇hd| 国产日产欧产精品精品推荐免费| 又色又爽又黄的美女裸体网站| 三上悠亚ssⅰn939无码播放| 国产综合精品| 国产成人亚洲日韩欧美| 天堂无码人妻精品一区二区三区| 999zyz玖玖资源站永久| 伊人久久大香线蕉av网站| 67194熟妇在线直接进入| 久久狠狠高潮亚洲精品| 亚洲成av人在线视猫咪| 欧美成人aa大片|