Recombinant Human UbiA prenyltransferase domain-containing protein 1 (UBIAD1 TERE1)

中文名稱：
貨號：

CSB-YP2302HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP2302HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP2302HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP2302HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP2302HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

UBIA1
Uniprot No.：

Q9Y5Z9
別名：

UbiA prenyltransferase domain-containing protein 1; EC 2.5.1.-; EC 2.5.1.39; Transitional epithelial response protein 1; UBIAD1 TERE1
種屬：

Homo sapiens (Human)
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
基因功能參考文獻：
1. The novel p.Thr120Arg is the fourth Schnyder corneal dystrophy-causing variant lying within the FARM motif of the UBIAD1 protein, which underlines a high importance of this motif for SCD pathogenesis. PMID: 30084067
2. Although de novo occurrence of mutations in UBIAD1 is extremely rare, SCD should be considered in the differential diagnosis of bilateral corneal haze and/or crystal deposition, especially in children PMID: 30223810
3. Silencing UBIAD1 further aggravates the deleterious effects rendered by Ang II, indicating that a normal or increased level of UBIAD1 may offer protection against the Ang IIinduced hypertrophic response and apoptosis. PMID: 28901410
4. these findings disclose a novel sensing mechanism that allows for stringent metabolic control of intracellular trafficking of UBIAD1, which directly modulates reductase degradation and becomes disrupted in Schnyder corneal dystrophy (SCD). PMID: 27121042
5. UBIAD1 or menaquinone-4 could decrease vascular cell differentiation and calcification, probably via its potent role of inversely modulating cellular cholesterol. PMID: 26890002
6. The conserved domain I is a substrate recognition site that undergoes a structural change after substrate binding. PMID: 25874989
7. Data show that sterols stimulate binding of prenyltransferase UBIAD1 to HMG CoA reductase, which is subject to sterol-accelerated, endoplasmic reticulum (ER)-associated degradation augmented by the nonsterol isoprenoid geranylgeraniol. PMID: 25742604
8. results suggest that YY1 up-regulates UBIAD1 expression and UBIAD1 conversion activity through the UBIAD1 promoter PMID: 25772619
9. N102S may also be a mutation hotspot in the Polish population, as in other previously reported populations. PMID: 24608252
10. Golgi localization of UBIAD1 influences its tumor suppressant activity. PMID: 23977195
11. Loss of TERE1 may contribute to the altered lipid metabolic phenotype associated with progression in renal clear cell carcinoma via an uncoupling of reactive oxygen species/nitric oxide and SXR signaling from apoptosis by elevation of cholesterol. PMID: 23759948
12. Physical association of UBIAD1 with enzymes involved in cholesterol synthesis and storage, providing direct links between UBIAD1 and cholesterol metabolism that are likely relevant to Schnyder corneal dystrophy disease pathology. PMID: 23169578
13. UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. PMID: 23533172
14. Findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity. PMID: 23374346
15. The nonsynonymous mutation, N102S, in the UBIAD1 gene has been detected in in a four-generation Chinese family with Schnyder corneal dystrophy (SCD). PMID: 22065921
16. the inhibitory effects of ectopic TERE1 expression on tumorigenic growth PMID: 21740188
17. results show that UBIAD1 is a human MK-4 biosynthetic enzyme; this identification will permit more effective decisions to be made about vitamin K intake and bone health PMID: 20953171
18. UBIAD1 encodes a menaquinone-4 biosynthetic enzyme that converts phylloquinone (PK) to menaquinone-4 (MK-4) PMID: 20953171
19. Our newly reported UBIAD1 mutation suggests that central discoid corneal dystrophy (CDCD) is actually a variant of schnyder corneal dystrophy. PMID: 20489584
20. Mitochondrial UBIAD1 protein appears to have a highly conserved function that, at least in humans, is involved in cholesterol metabolism in a novel manner. PMID: 20505825
21. Data suggest that UBIAD1 encodes a potential prenyltransferase, and may play a direct role in intracellular cholesterol biochemistry, or may prenylate other proteins regulating cholesterol transport and storage. PMID: 17668063
22. TERE1 maybe significant in prostate cancer growth regulation and the down regulation or absence of TERE1 may be an important component of the phenotype of advanced disease PMID: 12497587
23. The objective of this study was to gain further insight into the function of the TERE1 protein by identifying potential protein to protein interactions with TERE1 PMID: 15782423
24. Missense mutations in UBIAD1, located just outside of originally described Schnyder crystalline corneal dystrophy(SCCD) fine mapped region, were identified in each of three families with SCCD, confirming that mutations in UBIAD1 are associated with SCCD. PMID: 17960116
25. Nonsynonymous mutations in the UBIAD1 gene were detected in six SCCD (Schnyder crystalline corneal dystrophy) families, and a potential mutation hot spot was observed at amino acid N102. PMID: 17962451
26. Schnyder crystalline corneal dystrophy mutations affect function, ligand binding and interaction with binding partners, like apolipoproteins E. PMID: 18176953
27. Nonsynonymous novel mutations in the UBIAD1 gene were detected in 3 unrelated Japanese pedigrees with Schnyder's crystalline corneal dystrophy (SCCD), confirming the genetic heterogeneity of this disorder. PMID: 19394700
28. Screening of the UBIAD1 gene identified a highly conserved mutation, Ser171Pro in a chinese family. PMID: 19429578
29. The newly identified mutation expands the spectrum of mutations in UBIAD1 that may cause pathological corneal cholesterol deposition. PMID: 19649163
顯示更多

收起更多
相關(guān)疾病：

Corneal dystrophy, Schnyder type (SCCD)
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus.
蛋白家族：

UbiA prenyltransferase family
組織特異性：

Ubiquitously expressed.
數(shù)據(jù)庫鏈接：

HGNC: 30791

OMIM: 121800

KEGG: hsa:29914

STRING: 9606.ENSP00000366006

UniGene: Hs.522933