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UBIAD1 Antibody

  • 中文名稱:
    UBIAD1兔多克隆抗體
  • 貨號:
    CSB-PA23029A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of HepG2 cells with CSB-PA23029A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBIAD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UBIAD1
  • 別名:
    RP4-796F18.1 antibody; SCCD antibody; TERE 1 antibody; tere1 antibody; Transitional epithelia response protein antibody; Transitional epithelial response protein 1 antibody; UbiA prenyltransferase domain containing 1 antibody; UbiA prenyltransferase domain containing protein 1 antibody; UbiA prenyltransferase domain-containing protein 1 antibody; UBIA1_HUMAN antibody; UBIAD 1 antibody; Ubiad1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human UbiA prenyltransferase domain-containing protein 1 protein (1-82AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,UBIAD1 Antibody (CSB-PA23029A0Rb),的標記方式是Non-conjugated。對于UBIAD1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA23029B0Rb UBIAD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA23029C0Rb UBIAD1 Antibody, FITC conjugated
    Biotin CSB-PA23029D0Rb UBIAD1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
  • 基因功能參考文獻:
    1. The novel p.Thr120Arg is the fourth Schnyder corneal dystrophy-causing variant lying within the FARM motif of the UBIAD1 protein, which underlines a high importance of this motif for SCD pathogenesis. PMID: 30084067
    2. Although de novo occurrence of mutations in UBIAD1 is extremely rare, SCD should be considered in the differential diagnosis of bilateral corneal haze and/or crystal deposition, especially in children PMID: 30223810
    3. Silencing UBIAD1 further aggravates the deleterious effects rendered by Ang II, indicating that a normal or increased level of UBIAD1 may offer protection against the Ang IIinduced hypertrophic response and apoptosis. PMID: 28901410
    4. these findings disclose a novel sensing mechanism that allows for stringent metabolic control of intracellular trafficking of UBIAD1, which directly modulates reductase degradation and becomes disrupted in Schnyder corneal dystrophy (SCD). PMID: 27121042
    5. UBIAD1 or menaquinone-4 could decrease vascular cell differentiation and calcification, probably via its potent role of inversely modulating cellular cholesterol. PMID: 26890002
    6. The conserved domain I is a substrate recognition site that undergoes a structural change after substrate binding. PMID: 25874989
    7. Data show that sterols stimulate binding of prenyltransferase UBIAD1 to HMG CoA reductase, which is subject to sterol-accelerated, endoplasmic reticulum (ER)-associated degradation augmented by the nonsterol isoprenoid geranylgeraniol. PMID: 25742604
    8. results suggest that YY1 up-regulates UBIAD1 expression and UBIAD1 conversion activity through the UBIAD1 promoter PMID: 25772619
    9. N102S may also be a mutation hotspot in the Polish population, as in other previously reported populations. PMID: 24608252
    10. Golgi localization of UBIAD1 influences its tumor suppressant activity. PMID: 23977195
    11. Loss of TERE1 may contribute to the altered lipid metabolic phenotype associated with progression in renal clear cell carcinoma via an uncoupling of reactive oxygen species/nitric oxide and SXR signaling from apoptosis by elevation of cholesterol. PMID: 23759948
    12. Physical association of UBIAD1 with enzymes involved in cholesterol synthesis and storage, providing direct links between UBIAD1 and cholesterol metabolism that are likely relevant to Schnyder corneal dystrophy disease pathology. PMID: 23169578
    13. UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. PMID: 23533172
    14. Findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity. PMID: 23374346
    15. The nonsynonymous mutation, N102S, in the UBIAD1 gene has been detected in in a four-generation Chinese family with Schnyder corneal dystrophy (SCD). PMID: 22065921
    16. the inhibitory effects of ectopic TERE1 expression on tumorigenic growth PMID: 21740188
    17. results show that UBIAD1 is a human MK-4 biosynthetic enzyme; this identification will permit more effective decisions to be made about vitamin K intake and bone health PMID: 20953171
    18. UBIAD1 encodes a menaquinone-4 biosynthetic enzyme that converts phylloquinone (PK) to menaquinone-4 (MK-4) PMID: 20953171
    19. Our newly reported UBIAD1 mutation suggests that central discoid corneal dystrophy (CDCD) is actually a variant of schnyder corneal dystrophy. PMID: 20489584
    20. Mitochondrial UBIAD1 protein appears to have a highly conserved function that, at least in humans, is involved in cholesterol metabolism in a novel manner. PMID: 20505825
    21. Data suggest that UBIAD1 encodes a potential prenyltransferase, and may play a direct role in intracellular cholesterol biochemistry, or may prenylate other proteins regulating cholesterol transport and storage. PMID: 17668063
    22. TERE1 maybe significant in prostate cancer growth regulation and the down regulation or absence of TERE1 may be an important component of the phenotype of advanced disease PMID: 12497587
    23. The objective of this study was to gain further insight into the function of the TERE1 protein by identifying potential protein to protein interactions with TERE1 PMID: 15782423
    24. Missense mutations in UBIAD1, located just outside of originally described Schnyder crystalline corneal dystrophy(SCCD) fine mapped region, were identified in each of three families with SCCD, confirming that mutations in UBIAD1 are associated with SCCD. PMID: 17960116
    25. Nonsynonymous mutations in the UBIAD1 gene were detected in six SCCD (Schnyder crystalline corneal dystrophy) families, and a potential mutation hot spot was observed at amino acid N102. PMID: 17962451
    26. Schnyder crystalline corneal dystrophy mutations affect function, ligand binding and interaction with binding partners, like apolipoproteins E. PMID: 18176953
    27. Nonsynonymous novel mutations in the UBIAD1 gene were detected in 3 unrelated Japanese pedigrees with Schnyder's crystalline corneal dystrophy (SCCD), confirming the genetic heterogeneity of this disorder. PMID: 19394700
    28. Screening of the UBIAD1 gene identified a highly conserved mutation, Ser171Pro in a chinese family. PMID: 19429578
    29. The newly identified mutation expands the spectrum of mutations in UBIAD1 that may cause pathological corneal cholesterol deposition. PMID: 19649163

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  • 相關疾病:
    Corneal dystrophy, Schnyder type (SCCD)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus.
  • 蛋白家族:
    UbiA prenyltransferase family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 30791

    OMIM: 121800

    KEGG: hsa:29914

    STRING: 9606.ENSP00000366006

    UniGene: Hs.522933



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