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  4. Recombinant Human UPF0606 protein KIAA1549 (KIAA1549), partial

Recombinant Human UPF0606 protein KIAA1549 (KIAA1549), partial

  • 中文名稱：
    人KIAA1549重組蛋白
  • 貨號：
    CSB-YP867202HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KIAA1549重組蛋白
  • 貨號：
    CSB-EP867202HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KIAA1549重組蛋白
  • 貨號：
    CSB-EP867202HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KIAA1549重組蛋白
  • 貨號：
    CSB-BP867202HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KIAA1549重組蛋白
  • 貨號：
    CSB-MP867202HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KIAA1549
  • Uniprot No.：
  • 別名：
    KIAA1549; UPF0606 protein KIAA1549
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in photoreceptor function.
  • 基因功能參考文獻：
    1. This study demonstrated that when whole chromosome 7 gain accompanies the KIAA1549-BRAF fusion, the fusion likely arises first. PMID: 26945035
    2. Mutations in BRAF-KIAA1549 were associated with central nervous system tumors. PMID: 26115961
    3. This study confirmed the high frequency of KIAA1549:BRAF fusion in Pilocytic Astrocytomas. PMID: 26083571
    4. Pediatric oligodendrogliomas (pODGs) can harbor the KIAA1549-BRAF fusion with aberrant MAPK/ERK signaling, and there exists an option of targeting these pathways in such patients. PMID: 25794445
    5. we identify KIAA1549-BRAF gene fusions in 45 % of 82 low-grade glioma samples PMID: 24532263
    6. Molecular genetic analysis revealed BRAF duplication and a KIAA1549-BRAF fusion gene in 82% of group II tumors, but in none of the group I tumors, and a BRAF:p.V600E mutation in 43% of group I tumors, but in none of the group II tumors. PMID: 24529209
    7. Our results suggest that in a small fraction of diffuse gliomas, KIAA1549-BRAF fusion gene and BRAF(v600E) mutation may be responsible for deregulation of the Ras-RAF-ERK signaling pathway PMID: 22591444
    8. we found no cases of Rosette-forming glioneuronal tumors of the fourth ventricle showing KIAA1549-BRAF gene fusion or BRAF (V600E) mutation PMID: 22814862
    9. The frequency of BRAF-KIAA1549 fusion transcripts is significantly lower in adult patients with pilocytic astrocytoma. PMID: 21696415
    10. KIAA1549:BRAF fusions predominate in pilocytic astrocytomas but are also present in some low-grade unclassifiable gliomas and glioneuronal tumors. PMID: 22157620
    11. KIAA1549 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518

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  • 相關疾病：
    A chromosomal aberration involving KIAA1549 is found in pilocytic astrocytoma. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation.
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cell projection, cilium.
  • 蛋白家族：
    UPF0606 family
  • 組織特異性：
    [Isoform 1]: Expression is low to moderate in retina and tissues, such as heart and kidney, and is predominantly expressed in brain.; [Isoform 4]: Abundantly expressed in the retina, compared with only minimal expression in brain and other tissues.
  • 數據庫鏈接：

    HGNC: 22219

    OMIM: 613344

    KEGG: hsa:57670

    STRING: 9606.ENSP00000416040

    UniGene: Hs.605380



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