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Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2), partial

  • 中文名稱:
    Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2),partial
  • 貨號:
    CSB-YP822760HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2),partial
  • 貨號:
    CSB-EP822760HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2),partial
  • 貨號:
    CSB-EP822760HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2),partial
  • 貨號:
    CSB-BP822760HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2),partial
  • 貨號:
    CSB-MP822760HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    B3GALNT2
  • Uniprot No.:
  • 別名:
    3-GalNAc-T2; 3-N-acetylgalactosaminyltransferase 2; 3-N-acetylgalactosaminyltransferase II; B3GalNAc T2; B3GalNAcT2; b3galnt2; B3GL2_HUMAN; Beta 1,3 galactosaminyltransferase 2; Beta 1,3 N acetylgalactosaminyltransferase 2; Beta 1,3 N acetylgalactosaminyltransferase II; Beta 1,3 N acetylgalactosaminyltransferase II MGC39558; Beta 3 GalNAc T2; Beta-1; beta-1,3-GalNAc-T2; Beta3GalNAcT2; MDDGA11; MGC39558; UDP GalNAc:betaGlcNAc beta 1,3 galactosaminyltransferase polypeptide 2; UDP-GalNAc:beta-1; UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
  • 基因功能參考文獻:
    1. Mutations in B3GALNT2 give rise to a novel muscular dystrophy-dystroglycanopathies syndrome presentation, characterized by intellectual disability and seizure, but without any apparent muscular involvement. PMID: 29273094
    2. B3GALNT2 is a gene associated with congenital muscular dystrophy with brain malformations. PMID: 24084573
    3. B3GALNT2 overexpression is associated with breast cancer. PMID: 24285400
    4. Results demonstrate a role for B3GALNT2 in the glycosylation of alpha-DG and show that B3GALNT2 mutations can cause dystroglycanopathy with muscle and brain involvement. PMID: 23453667
    5. Although the GalNAcbeta1-3GlcNAcbeta1-R structure has not been reported in humans or other mammals, we have discovered a novel human glycosyltransferase producing this structure on N- and O-glycans. PMID: 14724282

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  • 相關疾?。?/div>
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11)
  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum.
  • 蛋白家族:
    Glycosyltransferase 31 family
  • 組織特異性:
    Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary.
  • 數據庫鏈接:

    HGNC: 28596

    OMIM: 610194

    KEGG: hsa:148789

    STRING: 9606.ENSP00000355559

    UniGene: Hs.498143



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