在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human UBX domain-containing protein 1 (UBXN1 SAKS1)

  • 中文名稱:
  • 貨號:
    CSB-YP2265HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2265HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2265HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2265HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2265HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    UBXN1
  • Uniprot No.:
  • 別名:
    UBX domain-containing protein 1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBXN1 SAKS1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
  • 基因功能參考文獻:
    1. The ability of UBXN1 and other family members to negatively regulate the NFkappaB pathway may be important for dampening the host immune response in disease processes and also re-activating quiescent HIV from latent viral reservoirs in chronically infected individuals PMID: 28152074
    2. p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. PMID: 27785701
    3. UBXN1 is a negative regulator of NF-kappaB signaling. PMID: 25681446
    4. UBXN1 is induced and recruited to MAVS after virus infection, serving as a brake to prevent excessive RLR signaling, most likely at a late stage of infection. PMID: 23545497
    5. SAKS1 inhibits protein degradation mediated by p97 complexes in the cytosol with a component of the mechanism being the ability to shield polyubiquitin chains from ubiquitin-processing factors. PMID: 21135095
    6. Data suggest that UBXN1 regulates the enzymatic function of BRCA1 in a manner that is dependent on its ubiquitination status. PMID: 20351172
    7. Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins. PMID: 15944415

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 數據庫鏈接:

    HGNC: 18402

    OMIM: 616378

    KEGG: hsa:51035

    STRING: 9606.ENSP00000294119

    UniGene: Hs.351296



主站蜘蛛池模板: 性xxxx欧美老妇胖老太269| 男女啪啪永久免费网站| 少妇中文字幕乱码亚洲影视| av片在线观看免费| 人妻中文字幕无码系列| 又粗又硬又黄又爽的视频永久 | 揉着我的奶从后面进去视频| 国产超碰人人爽人人做| 久久久久日韩精品免费观看| 国产亚洲曝欧美曝妖精品| 男人用嘴添女人下身免费视频| 又紧又大又爽精品一区二区| 亚洲精品卡2卡三卡4卡2卡乱码| 精品欧美小视频在线观看| 亚洲一区二区三区尿失禁| 97se亚洲国产综合自在线观看| 欧美丰满肥婆videos| 67pao国产成视频永久免费 | 久久久久久夜精品精品免费啦| 欧美激情视频一区二区三区免费| 久久久久人妻精品一区三寸| 韩国久久久久久级做爰片| 日韩亚洲欧美精品综合| 国产精品无码人妻一区二区在线| 女女同性av片在线观看免费 | 亚洲乱码在线卡一卡二卡新区| 亚洲狠狠婷婷综合久久| 久久精品人人槡人妻人| 人妻无码系列一区二区三区| 色悠久久久久综合网国产| 国产无遮挡又爽又刺激的视频老师| 免费无码又爽又刺激高潮软件| 狠日狠干日日射| 99亚洲男女激情在线观看| 97se亚洲国产综合自在线尤物| 亚洲成a∧人片在线播放无码| 天天躁夜夜躁av天天爽| 亚洲精品国产熟女久久久| 天天爽天天狠久久久综合麻豆| 狠狠综合久久综合88亚洲| 欲香欲色天天天综合和网|