在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBXN1 Antibody

UBXN1 Antibody

  • 中文名稱：
    UBXN1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025531GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UBXN1
  • 別名：
    UBXN1 antibody; SAKS1UBX domain-containing protein 1 antibody; SAPK substrate protein 1 antibody; UBA/UBX 33.3 kDa protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UBXN1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
  • 基因功能參考文獻(xiàn)：
    1. The ability of UBXN1 and other family members to negatively regulate the NFkappaB pathway may be important for dampening the host immune response in disease processes and also re-activating quiescent HIV from latent viral reservoirs in chronically infected individuals PMID: 28152074
    2. p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. PMID: 27785701
    3. UBXN1 is a negative regulator of NF-kappaB signaling. PMID: 25681446
    4. UBXN1 is induced and recruited to MAVS after virus infection, serving as a brake to prevent excessive RLR signaling, most likely at a late stage of infection. PMID: 23545497
    5. SAKS1 inhibits protein degradation mediated by p97 complexes in the cytosol with a component of the mechanism being the ability to shield polyubiquitin chains from ubiquitin-processing factors. PMID: 21135095
    6. Data suggest that UBXN1 regulates the enzymatic function of BRCA1 in a manner that is dependent on its ubiquitination status. PMID: 20351172
    7. Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins. PMID: 15944415

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18402

    OMIM: 616378

    KEGG: hsa:51035

    STRING: 9606.ENSP00000294119

    UniGene: Hs.351296



主站蜘蛛池模板： 欧美成人精品a∨在线观看| 无遮无挡爽爽免费视频| 国产成人啪精品视频免费网站软件 | 青青草国产三级精品三级| 一边摸一边做爽的免费视频日本| 欧美 日韩 国产 亚洲 色| 99久久国产露脸国语对白 | 好吊妞视频这里有精品| 夜夜爽一区二区三区精品| 精品香蕉久久久午夜福利| 天天躁日日躁狠狠躁人妻| 超清无码波多野吉衣中文| 中文字幕在线无码一区二区三区| 国产色无码精品视频国产| 99久久无码一区人妻a片蜜| 日本亚洲欧美日韩国产ay | 97高清国语自产拍| 风韵丰满熟妇啪啪区老老熟妇| 亚洲综合激情另类小说区| 免费va国产高清大片在线| 亚洲综合久久无码色噜噜| 麻豆一区二区99久久久久| 国产情侣一区二区三区| 国产偷伦视频片免费视频| 3d成人h动漫网站入口| 综合亚洲综合图区网友自拍| 精品久久久久中文字幕一区| 亚洲欧洲美洲无码精品va| 又湿又紧又大又爽又a视频| 97国产一区二区三区四区久久| 北条麻妃在线一区二区| 无码人妻精品一区二区三区久久久| 黄网站色成年片在线观看| 国产啪视频1000部免费| 人妻熟女一区二区aⅴ千叶宁真| 日韩精品人妻系列无码专区免费| 美女mm131爽爽爽作爱| 亚洲精品久久av无码麻| 22222se男人的天堂| 国产精品a成v人在线播放| 成人免费午夜无码视频在线播放|