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  4. Recombinant Human Tyrosine-protein kinase BAZ1B (BAZ1B), partial

Recombinant Human Tyrosine-protein kinase BAZ1B (BAZ1B), partial

  • 中文名稱：
    Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial
  • 貨號：
    CSB-YP883429HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial
  • 貨號：
    CSB-EP883429HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial
  • 貨號：
    CSB-EP883429HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial
  • 貨號：
    CSB-BP883429HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial
  • 貨號：
    CSB-MP883429HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BAZ1B
  • Uniprot No.：
  • 別名：
    baz1b; BAZ1B_HUMAN; Bromodomain adjacent to zinc finger domain protein 1B; hWALP 2; hWALP-2; hWALP2; transcription factor WSTF; Tyrosine-protein kinase BAZ1B; WALP-2; WALP2; WBRS 9; WBRS-9; WBRS9; WBSC 10; WBSC-10; WBSC10; WBSCR10; WBSCR9; Williams Beuren syndrome chromosome region 9 protein; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; WSTF
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication.
  • 基因功能參考文獻：
    1. promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID: 29021563
    2. Data show that Williams-Beuren syndrome transcription factor (WSTF) release was mediated by neuregulin-3 (NRG3) following KRASG12V expression in intestinal epithelial cells. PMID: 27449290
    3. WSTF may act as an oncoprotein in lung cancer to accelerate tumor aggressiveness. PMID: 27449264
    4. A pivotal role for BAZ1B in neurodevelopment was revealed and its haploinsufficiency was implicated as a likely contributor to the neurological phenotypes in Williams syndrome through transcriptional dysregulation. PMID: 26755828
    5. EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter. PMID: 23085504
    6. This review describes the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity. PMID: 21326359
    7. A multiprotein complex containing WSTF, nuclear myosin 1 (NM1), and SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 5 protein(SNF2h) is required for ribosomal DNA transcription. PMID: 16514417
    8. WSTF phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response PMID: 19092802

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  • 相關疾病：
    BAZ1B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BAZ1B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WAL family, BAZ1B subfamily
  • 組織特異性：
    Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
  • 數據庫鏈接：

    HGNC: 961

    OMIM: 605681

    KEGG: hsa:9031

    STRING: 9606.ENSP00000342434

    UniGene: Hs.743372



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