在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), partial

  • 中文名稱:
    人TNFRSF21重組蛋白
  • 貨號:
    CSB-EP023979HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    TNFRSF21
  • Uniprot No.:
  • 別名:
    TNFRSF 21; BM 018; BM018; CD358; Death receptor 6; DR 6; DR6; MGC31965; OTTHUMP00000039915; TNFR related death receptor 6; TNFRSF21; TNFRSF21 protein; TNR21_HUMAN; Tumor necrosis factor receptor superfamily member 21; Tumor necrosis factor receptor superfamily member 21 precursor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Cytoplasmic Domain
  • 來源:
    E.coli
  • 分子量:
    48.0kDa
  • 表達區域:
    371-655aa
  • 氨基酸序列
    RKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
  • 基因功能參考文獻:
    1. MiR20a5p functioned as an oncogene in HNSCC by downregulating TNFRSF21. PMID: 29901115
    2. Knockdown death receptor 6 by shRNA in human pDCs cell line GEN2.2 significantly diminished the CpG-ODN induced IFN-regulatory factor 7 nuclear localization and IFN-I production. PMID: 26906057
    3. data identify a new mechanism underlying tumour cell extravasation and metastasis, and suggest endothelial DR6-mediated necroptotic signalling pathways as targets for anti-metastatic therapies PMID: 27487218
    4. Increase in the expression levels of mRNA and protein for the death receptor 6 is associated with various types of gynaecological malignancy. PMID: 25113253
    5. Circulating levels of DR6 and Gpm6B correlate with breast cancer tumor grade. PMID: 24696529
    6. The present findings suggested that DR6 is involved in the pathogenesis of endometriosis by creating the proliferative and anti-apoptotic characteristics of endometriosis. PMID: 24028773
    7. Our results support the view that DR6 functions with APP to modulate synaptic density in the adult CNS PMID: 24806669
    8. These results provide direct support for the model that APP and DR6 function cell autonomously and in the same pathway to control pruning PMID: 24806670
    9. our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody. PMID: 24374337
    10. DR6 knockout mice are viable and fertile, and show hyperproliferation of T cells when stimulated. PMID: 11714751
    11. DR6 mediates T cell proliferation and differentiation in mice. PMID: 11485735
    12. DR6-induced apoptosis occurs through a new pathway that is different from the type I and type II pathways through interacting with Bax. PMID: 22761420
    13. DR6 serum protein may be a tool to aid in the diagnosis of some sarcomatous tumors to improve treatment planning. PMID: 22567163
    14. SAXS measurements on the ectodomain suggested that a dimer defines the minimal physical unit of an unliganded DR6 molecule in solution. PMID: 22525750
    15. findings show that DR6 expression is significantly but transiently upregulated only in activated both CD4+ and CD8+ T cells in NF-kappaB and NF-AT dependent manner with a contribution of PI3K-dependent signaling PMID: 21501873
    16. The model is used to provide a satisfying structural and energetic interpretation of DR6-growth factor-like domain of NAPP binding and to suggest the possibility of and a mechanism for spontaneous apoptosis. PMID: 21337622
    17. androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-alpha and DR6 PMID: 15623156
    18. MMP-14 and DR6 are part of a mechanism tumor cells can employ to actively escape detection by the immune system by affecting the generation of antigen presenting cells PMID: 17962943
    19. N-glycosylation of the extracellular part might participate in directing DR6 into lipid raft membrane microdomains. PMID: 19654028

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, sk
  • 數據庫鏈接:

    HGNC: 13469

    OMIM: 605732

    KEGG: hsa:27242

    STRING: 9606.ENSP00000296861

    UniGene: Hs.443577



主站蜘蛛池模板: 粗大的内捧猛烈进出在线视频| 最新国产成人无码久久| 亚洲va在线∨a天堂va欧美va| 久久精品国产导航| 亚洲日韩在线中文字幕线路2区 | 久久亚洲国产最新网站之一| 免费无码av片流白浆在线观看| 精品欧美一区二区三区久久久| 久久综合狠狠色综合伊人| 国产高清乱码又大又圆| 久久国产亚洲精选av| 欧美日韩亚洲国产精品| 真人抽搐一进一出gif| 五月丁香啪啪激情综合色九色| 2021国产成人精品久久| 亚洲男人的天堂在线播放| 成人免费视频在线观看| 免费人成又黄又爽的视频| 亚洲欧美乱综合图片区小说区| 在厨房被c到高潮a毛片奶水| 亚洲红杏成在人线免费视频| 亚洲第一天堂无码专区| 日韩欧群交p片内射中文| 久久精品人妻少妇一区二区三区| 天堂最新版资源网| 亚洲一区二区三区在线网址| 国产午夜亚洲精品午夜鲁丝片 | 欧美人与动交视频在线观看| 国产精品高潮呻吟av久久黄 | 国产精品视频免费播放| 狼人亚洲国内精品自在线| 国产精品av一区二区三区不卡蜜| 久久国产中文娱乐网| 久久国产欧美日韩精品图片| 亚洲丁香五月激情综合| 人人妻人人澡av天堂香蕉| 久久久性色精品国产免费观看 | 国产精品无码av一区二区三区 | 国产高清亚洲精品视bt天堂频| 亚洲乱亚洲乱妇无码麻豆| 国产超碰人人模人人爽人人添|