在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TNFRSF21 Antibody

TNFRSF21 Antibody

  • 中文名稱：
    TNFRSF21兔多克隆抗體
  • 貨號：
    CSB-PA023979DSR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: TNFRSF21 antibody at 4μg/ml
      Lane 1: K562 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 72 kDa
      Observed band size: 72 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023979DSR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TNFRSF21 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TNFRSF21
  • 別名：
    TNFRSF 21 antibody; BM 018 antibody; BM018 antibody; CD358 antibody; Death receptor 6 antibody; DR 6 antibody; DR6 antibody; MGC31965 antibody; OTTHUMP00000039915 antibody; TNFR related death receptor 6 antibody; TNFRSF21 antibody; TNFRSF21 protein antibody; TNR21_HUMAN antibody; Tumor necrosis factor receptor superfamily member 21 antibody; Tumor necrosis factor receptor superfamily member 21 precursor antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tumor necrosis factor receptor superfamily member 21 protein (371-655AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
  • 基因功能參考文獻(xiàn)：
    1. MiR20a5p functioned as an oncogene in HNSCC by downregulating TNFRSF21. PMID: 29901115
    2. Knockdown death receptor 6 by shRNA in human pDCs cell line GEN2.2 significantly diminished the CpG-ODN induced IFN-regulatory factor 7 nuclear localization and IFN-I production. PMID: 26906057
    3. data identify a new mechanism underlying tumour cell extravasation and metastasis, and suggest endothelial DR6-mediated necroptotic signalling pathways as targets for anti-metastatic therapies PMID: 27487218
    4. Increase in the expression levels of mRNA and protein for the death receptor 6 is associated with various types of gynaecological malignancy. PMID: 25113253
    5. Circulating levels of DR6 and Gpm6B correlate with breast cancer tumor grade. PMID: 24696529
    6. The present findings suggested that DR6 is involved in the pathogenesis of endometriosis by creating the proliferative and anti-apoptotic characteristics of endometriosis. PMID: 24028773
    7. Our results support the view that DR6 functions with APP to modulate synaptic density in the adult CNS PMID: 24806669
    8. These results provide direct support for the model that APP and DR6 function cell autonomously and in the same pathway to control pruning PMID: 24806670
    9. our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody. PMID: 24374337
    10. DR6 knockout mice are viable and fertile, and show hyperproliferation of T cells when stimulated. PMID: 11714751
    11. DR6 mediates T cell proliferation and differentiation in mice. PMID: 11485735
    12. DR6-induced apoptosis occurs through a new pathway that is different from the type I and type II pathways through interacting with Bax. PMID: 22761420
    13. DR6 serum protein may be a tool to aid in the diagnosis of some sarcomatous tumors to improve treatment planning. PMID: 22567163
    14. SAXS measurements on the ectodomain suggested that a dimer defines the minimal physical unit of an unliganded DR6 molecule in solution. PMID: 22525750
    15. findings show that DR6 expression is significantly but transiently upregulated only in activated both CD4+ and CD8+ T cells in NF-kappaB and NF-AT dependent manner with a contribution of PI3K-dependent signaling PMID: 21501873
    16. The model is used to provide a satisfying structural and energetic interpretation of DR6-growth factor-like domain of NAPP binding and to suggest the possibility of and a mechanism for spontaneous apoptosis. PMID: 21337622
    17. androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-alpha and DR6 PMID: 15623156
    18. MMP-14 and DR6 are part of a mechanism tumor cells can employ to actively escape detection by the immune system by affecting the generation of antigen presenting cells PMID: 17962943
    19. N-glycosylation of the extracellular part might participate in directing DR6 into lipid raft membrane microdomains. PMID: 19654028

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, sk
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13469

    OMIM: 605732

    KEGG: hsa:27242

    STRING: 9606.ENSP00000296861

    UniGene: Hs.443577



主站蜘蛛池模板： 在线看免费无码av天堂| 免费精品国偷自产在线2020| 免费播放婬乱男女婬视频国产 | 又紧又黄的免费视频网站| 精品久久久久久中文字幕大豆网 | 午夜精品国产精品大乳美女| 欧美两根一起进3p做受视频| 国产毛片一区二区精品| 18禁男女无遮挡啪啪网站| 亚洲 欧美 日韩 综合aⅴ视频| 少妇高潮灌满白浆毛片免费看| 国产性夜夜春夜夜爽1a片| 国产婷婷亚洲999精品小说| 国产精品久久国产精麻豆99网站 | 国产+成+人+亚洲欧洲自线| 欧洲av无码放荡人妇网站| 一本大道av伊人久久综合| 97国产精品人妻无码久久久| 国内精品久久久久影院中文字幕| 天堂最新版在线www官网中文地址| 亚洲aⅴ男人的天堂在线观看| 最爽无遮挡行房视频| 亚洲一区二区三区在线观看网站| 国产成人a∨麻豆精品| 奶头好大狂揉60分钟视频| 亚洲国产婷婷六月丁香| 爱色精品视频一区二区| 国产99久久久国产无需播放器| 国产裸体xxxx视频| 麻豆亚洲一区| 18禁亚洲深夜福利人口| 蜜臀少妇人妻在线| 成人午夜精品无码区久久| 一本无码人妻在中文字幕免费| 午夜电影网va内射| 亚洲综合激情五月丁香六月| 国产亚洲成av人片在线观黄桃| 青青爽无码视频在线观看| 久久亚洲精品中文字幕一区| 久久av高潮av无码av| 伦伦影院午夜理论片|