在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tripartite motif-containing protein 6 (TRIM6)

  • 中文名稱:
    人TRIM6重組蛋白
  • 貨號:
    CSB-YP863174HU
  • 說明書:
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TRIM6重組蛋白
  • 貨號:
    CSB-EP863174HU
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TRIM6重組蛋白
  • 貨號:
    CSB-EP863174HU-B
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TRIM6重組蛋白
  • 貨號:
    CSB-BP863174HU
  • 說明書:
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TRIM6重組蛋白
  • 貨號:
    CSB-MP863174HU
  • 說明書:
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TRIM6
  • Uniprot No.:
  • 別名:
    TRIM6; RNF89; Tripartite motif-containing protein 6; EC 2.3.2.27; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-488
  • 氨基酸序列
    MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells.
  • 基因功能參考文獻:
    1. Intriguingly, the authors also found that TRIM6 enhances ebola virus polymerase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious ebola virus, suggesting that VP35 hijacks TRIM6 to promote ebola virus replication through ubiquitination. PMID: 28679761
    2. Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains. PMID: 27622505
    3. TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKepsilon for subsequent STAT1 phosphorylation. PMID: 24882218
    4. heterologous RING, B-box 2, and CC domains from related TRIM proteins can functionally substitute for TRIM5alpha(rh) domains. PMID: 16775307
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    TRIM/RBCC family
  • 數(shù)據庫鏈接:

    HGNC: 16277

    OMIM: 607564

    KEGG: hsa:117854

    STRING: 9606.ENSP00000369440

    UniGene: Hs.729048



主站蜘蛛池模板: 色www视频永久免费| 日产欧美国产日韩精品| 韩国三级hd中文字幕叫床| 精品国产一区二区三区久久狼| 韩国 日本 亚洲 国产 不卡| 无码里番纯肉h在线网站| 无码不卡av东京热毛片| 色偷偷av男人的天堂| 国产极品美女到高潮无套| 97se狼狼狼狼狼亚洲网| 久久精品无码av| 丰满少妇人妻无码专区| 无码人妻精品一区二区三区99不卡| 日韩精品无码一本二本三本| 欧美老肥熟妇多毛xxxxx| 亚洲综合成人av一区在线观看| 欧美亚洲国产一区二区三区| 日日摸日日添日日碰9学生露脸| 国产福利日本一区二区三区| 中文字幕 亚洲精品 第1页| 小宝极品内射国产在线| 暖暖视频日本在线观看| 国产一区二区三区免费高清在线播放 | 免费看又黄又爽又猛的视频软件| 午夜性色福利在线视频福利| 日本xxx在线观看免费播放| 国产精品无码av在线播放| 亚洲欧美中文日韩在线v日本 | 热久久99这里有精品综合久久| 精品一区国产vr| 性色av无码一区二区三区人妻| 久久精品国产久精国产一老狼| 综合激情亚洲丁香社区| 久久久橹橹橹久久久久| 亚洲第一无码精品立川理惠| 免费人成在线观看网站品善网| 西西人体大胆无码视频| 亚洲人成电影网站在线观看 | 成人性三级欧美在线观看| 三级全黄的视频在线观看| 亚洲国产精品久久一线不卡|